DegronMD

Uniprot ID: Q14691

Source protein: DNA replication complex GINS protein PSF1

Source gene: GINS1

Class: DEG_APCC_DBOX_1

Location: 29:37

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6671

ASA_SCORE: 67.9778

COIL: 0.0084

CONS_SCORE: 0.4414

DSS_SCORE: 0.3913

HELIX: 0.9909

FCONS_SCORE: 1.2085

RIG_SCORE: 0.812

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S45F	TCGA-56-8625	LUSC	TCGA	LRQVLEEMK	DEG_APCC_DBOX_1	0.5556
p.S45F	DO45515	LUSC	ICGC	LRQVLEEMK	DEG_APCC_DBOX_1	0.5556
p.G28V	TCGA-A5-A0G2	UCEC	TCGA	LRQVLEEMK	DEG_APCC_DBOX_1	0.3056
p.G28V	DO41235	UCEC	ICGC	LRQVLEEMK	DEG_APCC_DBOX_1	0.3056
p.A38T	TCGA-AP-A059	UCEC	TCGA	LRQVLEEMK	DEG_APCC_DBOX_1	0.3056
p.A38T	TCGA-EO-A22R	UCEC	TCGA	LRQVLEEMK	DEG_APCC_DBOX_1	0.3056
p.A38T	DO42713	UCEC	ICGC	LRQVLEEMK	DEG_APCC_DBOX_1	0.3056
p.A38T	DO41361	UCEC	ICGC	LRQVLEEMK	DEG_APCC_DBOX_1	0.3056
p.N25S	TCGA-D8-A1J8	BRCA	TCGA	LRQVLEEMK	DEG_APCC_DBOX_1	0.2222
p.M36T	TCGA-DF-A2KU	UCEC	TCGA	LRQVLEEMK	DEG_APCC_DBOX_1	0.7423
p.M36T	DO223286	UCEC	ICGC	LRQVLEEMK	DEG_APCC_DBOX_1	0.7423
p.F24Y	TCGA-VQ-A8PT	STAD	TCGA	LRQVLEEMK	DEG_APCC_DBOX_1	0.1944
p.F24Y	DO51776	STAD	ICGC	LRQVLEEMK	DEG_APCC_DBOX_1	0.1944
p.P22S	TCGA-YJ-A8SW	PRAD	TCGA	LRQVLEEMK	DEG_APCC_DBOX_1	0.1389
p.P22S	DO219410	PRAD	ICGC	LRQVLEEMK	DEG_APCC_DBOX_1	0.1389
p.G19A	DO227520	ORCA	ICGC	LRQVLEEMK	DEG_APCC_DBOX_1	0.0556
p.E35G	SIDM01126	Small Cell Lung Carcinoma	GDSC	LRQVLEEMK	DEG_APCC_DBOX_1	0.6087
p.F24L	ACH-000836	Head and Neck Cancer	CCLE	LRQVLEEMK	DEG_APCC_DBOX_1	0.1944
p.E35K	ACH-002396	Bone Cancer	CCLE	LRQVLEEMK	DEG_APCC_DBOX_1	0.591
p.E35K	Sarc9371	bone	COSMIC	LRQVLEEMK	DEG_APCC_DBOX_1	0.591

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14691	DNA replication complex GINS protein PSF1	DEG_APCC_DBOX_1	29:37	LRQVLEEMK	APC,CDC20,FZR1	0.6671	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons