DegronMD - Q14699(RFTN1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R111I	TCGA-3N-A9WC	SKCM	TCGA	KTDLHNE	LIG_APCC_ABBAyCdc20_2	114:120	Mutation rewiring degron network	0.25
p.R111I	DO51234	SKCM	ICGC	KTDLHNE	LIG_APCC_ABBAyCdc20_2	114:120	Mutation rewiring degron network	0.25
p.I106M	TCGA-4Z-AA7W	BLCA	TCGA	KTDLHNE	LIG_APCC_ABBAyCdc20_2	114:120	Mutation rewiring degron network	0.1111
p.D127H	TCGA-A8-A09G	BRCA	TCGA	KTDLHNE	LIG_APCC_ABBAyCdc20_2	114:120	Mutation rewiring degron network	0.1389
p.Q113L	TCGA-DD-AACQ	LIHC	TCGA	KTDLHNE	LIG_APCC_ABBAyCdc20_2	114:120	Mutation rewiring degron network	0.3056
p.Q113L	DO52211	LIHC	ICGC	KTDLHNE	LIG_APCC_ABBAyCdc20_2	114:120	Mutation rewiring degron network	0.3056
p.D116V	TCGA-DU-6404	LGG	TCGA	KTDLHNE	LIG_APCC_ABBAyCdc20_2	114:120	Mutation altering degron motif	0.6674
p.D116V	DO22207	LGG	ICGC	KTDLHNE	LIG_APCC_ABBAyCdc20_2	114:120	Mutation altering degron motif	0.6674
p.S112Y	TCGA-F5-6814	READ	TCGA	KTDLHNE	LIG_APCC_ABBAyCdc20_2	114:120	Mutation rewiring degron network	0.2778
p.D116N	TCGA-FS-A1ZZ	SKCM	TCGA	KTDLHNE	LIG_APCC_ABBAyCdc20_2	114:120	Mutation altering degron motif	0.5821
p.I123M	TCGA-RS-A6TP	HNSC	TCGA	KTDLHNE	LIG_APCC_ABBAyCdc20_2	114:120	Mutation rewiring degron network	0.25
p.I123M	DO219062	HNSC	ICGC	KTDLHNE	LIG_APCC_ABBAyCdc20_2	114:120	Mutation rewiring degron network	0.25
p.V123G	DO10172	COAD	ICGC	KTDLHNE	LIG_APCC_ABBAyCdc20_2	114:120	Mutation rewiring degron network	0.25
p.D110E	DO228974	LICA	ICGC	KTDLHNE	LIG_APCC_ABBAyCdc20_2	114:120	Mutation rewiring degron network	0.2222
p.A115P	DO219131	LUSC	ICGC	KTDLHNE	LIG_APCC_ABBAyCdc20_2	114:120	Mutation altering degron motif	0.7503
p.V123I	DO52026	LUSC	ICGC	KTDLHNE	LIG_APCC_ABBAyCdc20_2	114:120	Mutation rewiring degron network	0.25
p.V125I	DO228396	MALY	ICGC	KTDLHNE	LIG_APCC_ABBAyCdc20_2	114:120	Mutation rewiring degron network	0.1944
p.Q113H	DO37851	SKCM	ICGC	KTDLHNE	LIG_APCC_ABBAyCdc20_2	114:120	Mutation rewiring degron network	0.3056
p.Q113H	DO38033	SKCM	ICGC	KTDLHNE	LIG_APCC_ABBAyCdc20_2	114:120	Mutation rewiring degron network	0.3056
p.H130Y	DO38404	STAD	ICGC	KTDLHNE	LIG_APCC_ABBAyCdc20_2	114:120	Mutation rewiring degron network	0.0556
p.K114E	ACH-001484	Leukemia	CCLE	KTDLHNE	LIG_APCC_ABBAyCdc20_2	114:120	Mutation altering degron motif	0.7022
p.K114E	ACH-001485	Leukemia	CCLE	KTDLHNE	LIG_APCC_ABBAyCdc20_2	114:120	Mutation altering degron motif	0.7022
p.Q128R	OPM-2	haematopoietic and lymphoid tissue	COSMIC	KTDLHNE	LIG_APCC_ABBAyCdc20_2	114:120	Mutation rewiring degron network	0.1111

Kaplan plot for RFTN1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RFTN1

UniProt ID: Q14699

Entrez ID: 23180

Protein name: Raftlin (Cell migration-inducing gene 2 protein) (Raft-linking protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RFTN1 in