DegronMD

Uniprot ID: Q14699

Source protein: Raftlin

Source gene: RFTN1

Class: LIG_APCC_ABBAyCdc20_2

Location: 114:120

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6065

ASA_SCORE: 98.4857

COIL: 0.8151

CONS_SCORE: 0.3636

DSS_SCORE: 0.2699

HELIX: 0.1243

FCONS_SCORE: 0.654

RIG_SCORE: 0.7558

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A115P	DO219131	LUSC	ICGC	KTDLHNE	LIG_APCC_ABBAyCdc20_2	0.7503
p.K114E	ACH-001484	Leukemia	CCLE	KTDLHNE	LIG_APCC_ABBAyCdc20_2	0.7022
p.K114E	ACH-001485	Leukemia	CCLE	KTDLHNE	LIG_APCC_ABBAyCdc20_2	0.7022
p.D116V	TCGA-DU-6404	LGG	TCGA	KTDLHNE	LIG_APCC_ABBAyCdc20_2	0.6674
p.D116V	DO22207	LGG	ICGC	KTDLHNE	LIG_APCC_ABBAyCdc20_2	0.6674
p.D116N	TCGA-FS-A1ZZ	SKCM	TCGA	KTDLHNE	LIG_APCC_ABBAyCdc20_2	0.5821
p.Q113L	TCGA-DD-AACQ	LIHC	TCGA	KTDLHNE	LIG_APCC_ABBAyCdc20_2	0.3056
p.Q113L	DO52211	LIHC	ICGC	KTDLHNE	LIG_APCC_ABBAyCdc20_2	0.3056
p.Q113H	DO37851	SKCM	ICGC	KTDLHNE	LIG_APCC_ABBAyCdc20_2	0.3056
p.Q113H	DO38033	SKCM	ICGC	KTDLHNE	LIG_APCC_ABBAyCdc20_2	0.3056
p.S112Y	TCGA-F5-6814	READ	TCGA	KTDLHNE	LIG_APCC_ABBAyCdc20_2	0.2778
p.R111I	TCGA-3N-A9WC	SKCM	TCGA	KTDLHNE	LIG_APCC_ABBAyCdc20_2	0.25
p.R111I	DO51234	SKCM	ICGC	KTDLHNE	LIG_APCC_ABBAyCdc20_2	0.25
p.I123M	TCGA-RS-A6TP	HNSC	TCGA	KTDLHNE	LIG_APCC_ABBAyCdc20_2	0.25
p.I123M	DO219062	HNSC	ICGC	KTDLHNE	LIG_APCC_ABBAyCdc20_2	0.25
p.V123G	DO10172	COAD	ICGC	KTDLHNE	LIG_APCC_ABBAyCdc20_2	0.25
p.V123I	DO52026	LUSC	ICGC	KTDLHNE	LIG_APCC_ABBAyCdc20_2	0.25
p.D110E	DO228974	LICA	ICGC	KTDLHNE	LIG_APCC_ABBAyCdc20_2	0.2222
p.V125I	DO228396	MALY	ICGC	KTDLHNE	LIG_APCC_ABBAyCdc20_2	0.1944
p.D127H	TCGA-A8-A09G	BRCA	TCGA	KTDLHNE	LIG_APCC_ABBAyCdc20_2	0.1389
p.I106M	TCGA-4Z-AA7W	BLCA	TCGA	KTDLHNE	LIG_APCC_ABBAyCdc20_2	0.1111
p.Q128R	OPM-2	haematopoietic_and_lymphoid_tissue	COSMIC	KTDLHNE	LIG_APCC_ABBAyCdc20_2	0.1111
p.H130Y	DO38404	STAD	ICGC	KTDLHNE	LIG_APCC_ABBAyCdc20_2	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14699	Raftlin	LIG_APCC_ABBAyCdc20_2	114:120	KTDLHNE	APC,CDC20,FZR1	0.6065	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons