DegronMD - Q14765(STAT4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S696F	TCGA-AC-A23H	BRCA	TCGA	TERGDKGYVPSV	DEG_COP1_1	686:697	Mutation altering degron motif	0.7982
p.S696F	DO2401	BRCA	ICGC	TERGDKGYVPSV	DEG_COP1_1	686:697	Mutation altering degron motif	0.7982
p.G692R	TCGA-AR-A0TS	BRCA	TCGA	TERGDKGYVPSV	DEG_COP1_1	686:697	Mutation altering degron motif	0.6457
p.G692R	DO4317	BRCA	ICGC	TERGDKGYVPSV	DEG_COP1_1	686:697	Mutation altering degron motif	0.6457
p.S683L	TCGA-CN-A640	HNSC	TCGA	TERGDKGYVPSV	DEG_COP1_1	686:697	Mutation rewiring degron network	0.25
p.S683L	DO52046	HNSC	ICGC	TERGDKGYVPSV	DEG_COP1_1	686:697	Mutation rewiring degron network	0.25
p.E681Q	TCGA-DD-AAC8	LIHC	TCGA	TERGDKGYVPSV	DEG_COP1_1	686:697	Mutation rewiring degron network	0.1944
p.E681Q	DO224600	BRCA	ICGC	TERGDKGYVPSV	DEG_COP1_1	686:697	Mutation rewiring degron network	0.1944
p.E681Q	DO1011	BRCA	ICGC	TERGDKGYVPSV	DEG_COP1_1	686:697	Mutation rewiring degron network	0.1944
p.E681Q	DO52193	LIHC	ICGC	TERGDKGYVPSV	DEG_COP1_1	686:697	Mutation rewiring degron network	0.1944
p.R688S	TCGA-EE-A2GE	SKCM	TCGA	TERGDKGYVPSV	DEG_COP1_1	686:697	Mutation altering degron motif	0.6316
p.R688S	DO38016	SKCM	ICGC	TERGDKGYVPSV	DEG_COP1_1	686:697	Mutation altering degron motif	0.6316
p.P695S	TCGA-EO-A3B0	UCEC	TCGA	TERGDKGYVPSV	DEG_COP1_1	686:697	Mutation altering degron motif	0.6752
p.P695S	DO219773	UCEC	ICGC	TERGDKGYVPSV	DEG_COP1_1	686:697	Mutation altering degron motif	0.6752
p.P700S	TCGA-FR-A726	SKCM	TCGA	TERGDKGYVPSV	DEG_COP1_1	686:697	Mutation rewiring degron network	0.25
p.P700S	DO48665	SKCM	ICGC	TERGDKGYVPSV	DEG_COP1_1	686:697	Mutation rewiring degron network	0.25
p.E681K	TCGA-FS-A1ZZ	SKCM	TCGA	TERGDKGYVPSV	DEG_COP1_1	686:697	Mutation rewiring degron network	0.1944
p.E681K	DO37412	SKCM	ICGC	TERGDKGYVPSV	DEG_COP1_1	686:697	Mutation rewiring degron network	0.1944
p.Q678E	TCGA-G2-A2EF	BLCA	TCGA	TERGDKGYVPSV	DEG_COP1_1	686:697	Mutation rewiring degron network	0.1111
p.Q678E	DO726	BLCA	ICGC	TERGDKGYVPSV	DEG_COP1_1	686:697	Mutation rewiring degron network	0.1111
p.E687Q	TCGA-L5-A8NQ	ESCA	TCGA	TERGDKGYVPSV	DEG_COP1_1	686:697	Mutation altering degron motif	0.6744
p.I701S	DO222857	BTCA	ICGC	TERGDKGYVPSV	DEG_COP1_1	686:697	Mutation rewiring degron network	0.2222
p.Q678R	DO229542	UTCA	ICGC	TERGDKGYVPSV	DEG_COP1_1	686:697	Mutation rewiring degron network	0.1111
p.Q678R	SIDM00500	Colorectal Carcinoma	GDSC	TERGDKGYVPSV	DEG_COP1_1	686:697	Mutation rewiring degron network	0.1111
p.Q678R	ACH-000959	Colon/Colorectal Cancer	CCLE	TERGDKGYVPSV	DEG_COP1_1	686:697	Mutation rewiring degron network	0.1111
p.D690E	SIDM01608	Endometrial Carcinoma	GDSC	TERGDKGYVPSV	DEG_COP1_1	686:697	Mutation altering degron motif	0.5647
p.D690E	ACH-000990	Endometrial/Uterine Cancer	CCLE	TERGDKGYVPSV	DEG_COP1_1	686:697	Mutation altering degron motif	0.5647
p.P679S	ACH-001523	Skin Cancer	CCLE	TERGDKGYVPSV	DEG_COP1_1	686:697	Mutation rewiring degron network	0.1389

Kaplan plot for STAT4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

STAT4

UniProt ID: Q14765

Entrez ID: 6775

Protein name: Signal transducer and activator of transcription 4

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for STAT4 in