DegronMD

Uniprot ID: Q14765

Source protein: Signal transducer and activator of transcription 4

Source gene: STAT4

Class: DEG_COP1_1

Location: 686:697

E3 ligase: COP1

DEGRON score: 0.993

ASA_SCORE: 73.3167

COIL: 0.7598

CONS_SCORE: 0.4149

DSS_SCORE: 0.4924

HELIX: 0.0278

FCONS_SCORE: 1.2248

RIG_SCORE: 0.7021

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S696F	TCGA-AC-A23H	BRCA	TCGA	TERGDKGYVPSV	DEG_COP1_1	0.7982
p.S696F	DO2401	BRCA	ICGC	TERGDKGYVPSV	DEG_COP1_1	0.7982
p.G692R	TCGA-AR-A0TS	BRCA	TCGA	TERGDKGYVPSV	DEG_COP1_1	0.6457
p.G692R	DO4317	BRCA	ICGC	TERGDKGYVPSV	DEG_COP1_1	0.6457
p.S683L	TCGA-CN-A640	HNSC	TCGA	TERGDKGYVPSV	DEG_COP1_1	0.25
p.S683L	DO52046	HNSC	ICGC	TERGDKGYVPSV	DEG_COP1_1	0.25
p.E681Q	TCGA-DD-AAC8	LIHC	TCGA	TERGDKGYVPSV	DEG_COP1_1	0.1944
p.E681Q	DO224600	BRCA	ICGC	TERGDKGYVPSV	DEG_COP1_1	0.1944
p.E681Q	DO1011	BRCA	ICGC	TERGDKGYVPSV	DEG_COP1_1	0.1944
p.E681Q	DO52193	LIHC	ICGC	TERGDKGYVPSV	DEG_COP1_1	0.1944
p.R688S	TCGA-EE-A2GE	SKCM	TCGA	TERGDKGYVPSV	DEG_COP1_1	0.6316
p.R688S	DO38016	SKCM	ICGC	TERGDKGYVPSV	DEG_COP1_1	0.6316
p.P695S	TCGA-EO-A3B0	UCEC	TCGA	TERGDKGYVPSV	DEG_COP1_1	0.6752
p.P695S	DO219773	UCEC	ICGC	TERGDKGYVPSV	DEG_COP1_1	0.6752
p.P700S	TCGA-FR-A726	SKCM	TCGA	TERGDKGYVPSV	DEG_COP1_1	0.25
p.P700S	DO48665	SKCM	ICGC	TERGDKGYVPSV	DEG_COP1_1	0.25
p.E681K	TCGA-FS-A1ZZ	SKCM	TCGA	TERGDKGYVPSV	DEG_COP1_1	0.1944
p.E681K	DO37412	SKCM	ICGC	TERGDKGYVPSV	DEG_COP1_1	0.1944
p.Q678E	TCGA-G2-A2EF	BLCA	TCGA	TERGDKGYVPSV	DEG_COP1_1	0.1111
p.Q678E	DO726	BLCA	ICGC	TERGDKGYVPSV	DEG_COP1_1	0.1111
p.E687Q	TCGA-L5-A8NQ	ESCA	TCGA	TERGDKGYVPSV	DEG_COP1_1	0.6744
p.I701S	DO222857	BTCA	ICGC	TERGDKGYVPSV	DEG_COP1_1	0.2222
p.Q678R	DO229542	UTCA	ICGC	TERGDKGYVPSV	DEG_COP1_1	0.1111
p.Q678R	SIDM00500	Colorectal Carcinoma	GDSC	TERGDKGYVPSV	DEG_COP1_1	0.1111
p.Q678R	ACH-000959	Colon/Colorectal Cancer	CCLE	TERGDKGYVPSV	DEG_COP1_1	0.1111
p.D690E	SIDM01608	Endometrial Carcinoma	GDSC	TERGDKGYVPSV	DEG_COP1_1	0.5647
p.D690E	ACH-000990	Endometrial/Uterine Cancer	CCLE	TERGDKGYVPSV	DEG_COP1_1	0.5647
p.P679S	ACH-001523	Skin Cancer	CCLE	TERGDKGYVPSV	DEG_COP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14765	Signal transducer and activator of transcription 4	DEG_COP1_1	686:697	TERGDKGYVPSV	COP1	0.993	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TERGDKGYVPSV

Degron related mutations and impact score

Drug responses associated with STAT4 mutations

All proteins holding degron of TERGDKGYVPSV