DegronMD - Q14814(MEF2D)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S301F	TCGA-EB-A41A	SKCM	TCGA	LTTPVVS	DEG_SCF_FBW7_1	307:313	Mutation rewiring degron network	0.1667
p.G299V	TCGA-GN-A26D	SKCM	TCGA	LTTPVVS	DEG_SCF_FBW7_1	307:313	Mutation rewiring degron network	0.1111
p.H305Y	TCGA-IR-A3LI	CESC	TCGA	LTTPVVS	DEG_SCF_FBW7_1	307:313	Mutation rewiring degron network	0.2778
p.S311P	DO10880	GBM	ICGC	LTTPVVS	DEG_SCF_FBW7_1	307:313	Mutation altering degron motif	0.6752
p.P321Q	DO229022	LICA	ICGC	LTTPVVS	DEG_SCF_FBW7_1	307:313	Mutation rewiring degron network	0.1111
p.H305L	SIDM00586	Hepatocellular Carcinoma	GDSC	LTTPVVS	DEG_SCF_FBW7_1	307:313	Mutation rewiring degron network	0.2778
p.H305L	SIDM00367	Small Cell Lung Carcinoma	GDSC	LTTPVVS	DEG_SCF_FBW7_1	307:313	Mutation rewiring degron network	0.2778
p.H305L	huH-1	liver	COSMIC	LTTPVVS	DEG_SCF_FBW7_1	307:313	Mutation rewiring degron network	0.2778
p.H305L	SBC-3	lung	COSMIC	LTTPVVS	DEG_SCF_FBW7_1	307:313	Mutation rewiring degron network	0.2778
p.T316M	SIDM00946	T-Lymphoblastic Leukemia	GDSC	LTTPVVS	DEG_SCF_FBW7_1	307:313	Mutation rewiring degron network	0.25
p.T316M	ACH-000981	Leukemia	CCLE	LTTPVVS	DEG_SCF_FBW7_1	307:313	Mutation rewiring degron network	0.25
p.T316M	DND-41	haematopoietic and lymphoid tissue	COSMIC	LTTPVVS	DEG_SCF_FBW7_1	307:313	Mutation rewiring degron network	0.25
p.S306L	SIDM00364	B-Lymphoblastic Leukemia	GDSC	LTTPVVS	DEG_SCF_FBW7_1	307:313	Mutation rewiring degron network	0.3056
p.S306L	ACH-002059	Leukemia	CCLE	LTTPVVS	DEG_SCF_FBW7_1	307:313	Mutation rewiring degron network	0.3056
p.S306L	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	LTTPVVS	DEG_SCF_FBW7_1	307:313	Mutation rewiring degron network	0.3056
p.P310L	ACH-000961	Endometrial/Uterine Cancer	CCLE	LTTPVVS	DEG_SCF_FBW7_1	307:313	Mutation altering degron motif	0.7582
p.T309M	DND-41	haematopoietic and lymphoid tissue	COSMIC	LTTPVVS	DEG_SCF_FBW7_1	307:313	Mutation altering degron motif	0.7423
p.T308M	DND-41	haematopoietic and lymphoid tissue	COSMIC	LTTPVVS	DEG_SCF_FBW7_1	307:313	Mutation altering degron motif	0.6312
p.H298L	huH-1	liver	COSMIC	LTTPVVS	DEG_SCF_FBW7_1	307:313	Mutation rewiring degron network	0.0833
p.H298L	SBC-3	lung	COSMIC	LTTPVVS	DEG_SCF_FBW7_1	307:313	Mutation rewiring degron network	0.0833
p.H297L	SBC-3	lung	COSMIC	LTTPVVS	DEG_SCF_FBW7_1	307:313	Mutation rewiring degron network	0.0556
p.H297L	huH-1	liver	COSMIC	LTTPVVS	DEG_SCF_FBW7_1	307:313	Mutation rewiring degron network	0.0556
p.S299L	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	LTTPVVS	DEG_SCF_FBW7_1	307:313	Mutation rewiring degron network	0.1111
p.S298L	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	LTTPVVS	DEG_SCF_FBW7_1	307:313	Mutation rewiring degron network	0.0833

Kaplan plot for MEF2D in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MEF2D

UniProt ID: Q14814

Entrez ID: 4209

Protein name: Myocyte-specific enhancer factor 2D

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MEF2D in