DegronMD

Uniprot ID: Q14814

Source protein: Myocyte-specific enhancer factor 2D

Source gene: MEF2D

Class: DEG_SCF_FBW7_1

Location: 307:313

E3 ligase: FBXW7

DEGRON score: 0.9871

ASA_SCORE: 77.3571

COIL: 0.9321

CONS_SCORE: 0.3554

DSS_SCORE: 0.3864

HELIX: 0.0233

FCONS_SCORE: 1.0585

RIG_SCORE: 0.7495

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S301F	TCGA-EB-A41A	SKCM	TCGA	LTTPVVS	DEG_SCF_FBW7_1	0.1667
p.G299V	TCGA-GN-A26D	SKCM	TCGA	LTTPVVS	DEG_SCF_FBW7_1	0.1111
p.H305Y	TCGA-IR-A3LI	CESC	TCGA	LTTPVVS	DEG_SCF_FBW7_1	0.2778
p.S311P	DO10880	GBM	ICGC	LTTPVVS	DEG_SCF_FBW7_1	0.6752
p.P321Q	DO229022	LICA	ICGC	LTTPVVS	DEG_SCF_FBW7_1	0.1111
p.H305L	SIDM00586	Hepatocellular Carcinoma	GDSC	LTTPVVS	DEG_SCF_FBW7_1	0.2778
p.H305L	SIDM00367	Small Cell Lung Carcinoma	GDSC	LTTPVVS	DEG_SCF_FBW7_1	0.2778
p.H305L	huH-1	liver	COSMIC	LTTPVVS	DEG_SCF_FBW7_1	0.2778
p.H305L	SBC-3	lung	COSMIC	LTTPVVS	DEG_SCF_FBW7_1	0.2778
p.T316M	SIDM00946	T-Lymphoblastic Leukemia	GDSC	LTTPVVS	DEG_SCF_FBW7_1	0.25
p.T316M	ACH-000981	Leukemia	CCLE	LTTPVVS	DEG_SCF_FBW7_1	0.25
p.T316M	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	LTTPVVS	DEG_SCF_FBW7_1	0.25
p.S306L	SIDM00364	B-Lymphoblastic Leukemia	GDSC	LTTPVVS	DEG_SCF_FBW7_1	0.3056
p.S306L	ACH-002059	Leukemia	CCLE	LTTPVVS	DEG_SCF_FBW7_1	0.3056
p.S306L	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	LTTPVVS	DEG_SCF_FBW7_1	0.3056
p.P310L	ACH-000961	Endometrial/Uterine Cancer	CCLE	LTTPVVS	DEG_SCF_FBW7_1	0.7582
p.T309M	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	LTTPVVS	DEG_SCF_FBW7_1	0.7423
p.T308M	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	LTTPVVS	DEG_SCF_FBW7_1	0.6312
p.H298L	huH-1	liver	COSMIC	LTTPVVS	DEG_SCF_FBW7_1	0.0833
p.H298L	SBC-3	lung	COSMIC	LTTPVVS	DEG_SCF_FBW7_1	0.0833
p.H297L	SBC-3	lung	COSMIC	LTTPVVS	DEG_SCF_FBW7_1	0.0556
p.H297L	huH-1	liver	COSMIC	LTTPVVS	DEG_SCF_FBW7_1	0.0556
p.S299L	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	LTTPVVS	DEG_SCF_FBW7_1	0.1111
p.S298L	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	LTTPVVS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14814	Myocyte-specific enhancer factor 2D	DEG_SCF_FBW7_1	307:313	LTTPVVS	FBXW7	0.9871	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTTPVVS

Degron related mutations and impact score

Drug responses associated with MEF2D mutations

All proteins holding degron of LTTPVVS