GRIN2C
UniProt ID: Q14957
Entrez ID: 2905
Protein name: Glutamate receptor ionotropic, NMDA 2C (GluN2C) (Glutamate [NMDA] receptor subunit epsilon-3) (N-methyl D-aspartate receptor subtype 2C) (NMDAR2C) (NR2C)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to ...
FUNCTION: Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:26875626). Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable). Plays a role in regulating the balance between excitatory and inhibitory activity of pyramidal neurons in the prefrontal cortex. Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity). {ECO:0000250|UniProtKB:Q01098, ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:28095420, ECO:0000305}.
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GO - Biological processes (BP):
brain development [GO:0007420]; calcium ion transmembrane import into cytosol [GO:0097553]; cation transmembrane transport [GO:0098655]; directional locomotion [GO:0033058]; excitatory chemical synaptic transmission [GO:0098976]; excitatory postsynaptic potential [GO:0060079]; glutamate receptor sig...
brain development [GO:0007420]; calcium ion transmembrane import into cytosol [GO:0097553]; cation transmembrane transport [GO:0098655]; directional locomotion [GO:0033058]; excitatory chemical synaptic transmission [GO:0098976]; excitatory postsynaptic potential [GO:0060079]; glutamate receptor signaling pathway [GO:0007215]; long-term synaptic potentiation [GO:0060291]; negative regulation of protein catabolic process [GO:0042177]; neuromuscular process controlling balance [GO:0050885]; protein localization to postsynaptic membrane [GO:1903539]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of synaptic plasticity [GO:0048167]; response to wounding [GO:0009611]
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GO - Molecular function (MF):
glutamate-gated calcium ion channel activity [GO:0022849]; ligand-gated ion channel activity [GO:0015276]; NMDA glutamate receptor activity [GO:0004972]; signaling receptor activity [GO:0038023]; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential [GO:190...
glutamate-gated calcium ion channel activity [GO:0022849]; ligand-gated ion channel activity [GO:0015276]; NMDA glutamate receptor activity [GO:0004972]; signaling receptor activity [GO:0038023]; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential [GO:1904315]
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GO - Cellular component (CC):
endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; integral component of plasma membrane [GO:0005887]; NMDA selective glutamate receptor complex [GO:0017146]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]...
endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; integral component of plasma membrane [GO:0005887]; NMDA selective glutamate receptor complex [GO:0017146]; plasma membrane [GO:0005886]; postsynaptic density membrane [GO:0098839]; postsynaptic membrane [GO:0045211]
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GRIN2C
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Kaplan plot for GRIN2C in
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*NOTE: the Kaplan plots were collected from OncoLnc