DegronMD

Uniprot ID: Q14957

Source protein: Glutamate receptor ionotropic, NMDA 2C

Source gene: GRIN2C

Class: LIG_APCC_ABBA_1

Location: 1043:1048

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7111

ASA_SCORE: 70.4

COIL: 0.8665

CONS_SCORE: 0.2609

DSS_SCORE: 0.303

HELIX: 0.041

FCONS_SCORE: 0.913

RIG_SCORE: 0.78

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1034Q	DO222708	MELA	ICGC	LPLFPE	LIG_APCC_ABBA_1	0.0833
p.S1038A	SIDM00931	Thyroid Gland Carcinoma	GDSC	LPLFPE	LIG_APCC_ABBA_1	0.1944
p.G1039D	ACH-000985	Colon/Colorectal Cancer	CCLE	LPLFPE	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14957	Glutamate receptor ionotropic, NMDA 2C	LIG_APCC_ABBA_1	1043:1048	LPLFPE	APC,CDC20,FZR1	0.7111	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons