PSME4
UniProt ID: Q14997
Entrez ID: 23198
Protein name: Proteasome activator complex subunit 4 (Proteasome activator PA200)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region a...
FUNCTION: Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks. {ECO:0000269|PubMed:12093752, ECO:0000269|PubMed:18845680, ECO:0000269|PubMed:22550082, ECO:0000269|PubMed:23706739}.
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GO - Biological processes (BP):
cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; spermatogenesis, exchange of chromosomal proteins [GO:0035093]...
cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; spermatogenesis, exchange of chromosomal proteins [GO:0035093]
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GO - Molecular function (MF):
lysine-acetylated histone binding [GO:0070577]; peptidase activator activity [GO:0016504]; proteasome binding [GO:0070628]...
lysine-acetylated histone binding [GO:0070577]; peptidase activator activity [GO:0016504]; proteasome binding [GO:0070628]
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GO - Cellular component (CC):
cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spermatoproteasome complex [GO:1990111]...
cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spermatoproteasome complex [GO:1990111]
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PSME4
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*NOTE: the Kaplan plots were collected from OncoLnc