DegronMD

Uniprot ID: Q14997

Source protein: Proteasome activator complex subunit 4

Source gene: PSME4

Class: LIG_APCC_ABBA_1

Location: 37:42

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6366

ASA_SCORE: 56.05

COIL: 0.7632

CONS_SCORE: 0.4089

DSS_SCORE: 0.2475

HELIX: 0.189

FCONS_SCORE: 1.2913

RIG_SCORE: 0.8524

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L38Q	DO46356	OV	ICGC	LLPYAE	LIG_APCC_ABBA_1	0.6654
p.A41G	ACH-000274	Skin Cancer	CCLE	LLPYAE	LIG_APCC_ABBA_1	0.6429
p.L50F	ACH-000894	Lung Cancer	CCLE	LLPYAE	LIG_APCC_ABBA_1	0.1111

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14997	Proteasome activator complex subunit 4	LIG_APCC_ABBA_1	37:42	LLPYAE	APC,CDC20,FZR1	0.6366	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons