DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LLPYAE
Uniprot ID:
Q14997
Source protein:
Proteasome activator complex subunit 4
Source gene:
PSME4
Class:
LIG_APCC_ABBA_1
Location:
37:42
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6366
ASA_SCORE:
56.05
COIL:
0.7632
CONS_SCORE:
0.4089
DSS_SCORE:
0.2475
HELIX:
0.189
FCONS_SCORE:
1.2913
RIG_SCORE:
0.8524
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.L38Q
DO46356
OV
ICGC
LLPYAE
LIG_APCC_ABBA_1
0.6654
p.A41G
ACH-000274
Skin Cancer
CCLE
LLPYAE
LIG_APCC_ABBA_1
0.6429
p.L50F
ACH-000894
Lung Cancer
CCLE
LLPYAE
LIG_APCC_ABBA_1
0.1111
Drug responses associated with PSME4 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LLPYAE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q14997
Proteasome activator complex subunit 4
LIG_APCC_ABBA_1
37:42
LLPYAE
APC,CDC20,FZR1
0.6366
More...