DegronMD - Q14BN4(SLMAP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A254S	TCGA-A5-A0G2	UCEC	TCGA	LRKELIALQ	DEG_APCC_DBOX_1	236:244	Mutation rewiring degron network	0.0556
p.A254S	DO41235	UCEC	ICGC	LRKELIALQ	DEG_APCC_DBOX_1	236:244	Mutation rewiring degron network	0.0556
p.E233A	DO233937	GACA	ICGC	LRKELIALQ	DEG_APCC_DBOX_1	236:244	Mutation rewiring degron network	0.25
p.S235I	DO228976	LICA	ICGC	LRKELIALQ	DEG_APCC_DBOX_1	236:244	Mutation blocking phosphorylation signal	0.75
p.N230S	DO229268	THCA	ICGC	LRKELIALQ	DEG_APCC_DBOX_1	236:244	Mutation rewiring degron network	0.1667
p.E251G	SIDM00190	Melanoma	GDSC	LRKELIALQ	DEG_APCC_DBOX_1	236:244	Mutation rewiring degron network	0.1389
p.E251G	ACH-002097	Skin Cancer	CCLE	LRKELIALQ	DEG_APCC_DBOX_1	236:244	Mutation rewiring degron network	0.1389
p.E251G	CP66-MEL	skin	COSMIC	LRKELIALQ	DEG_APCC_DBOX_1	236:244	Mutation rewiring degron network	0.1389
p.I241L	SIDM00683	Prostate Carcinoma	GDSC	LRKELIALQ	DEG_APCC_DBOX_1	236:244	Mutation altering degron motif	0.6063
p.I241L	ACH-000977	lymph node	CCLE	LRKELIALQ	DEG_APCC_DBOX_1	236:244	Mutation altering degron motif	0.6063
p.I241L	LNCaP-Clone-FGC	prostate	COSMIC	LRKELIALQ	DEG_APCC_DBOX_1	236:244	Mutation altering degron motif	0.6063
p.D234H	ACH-000837	Lung Cancer	CCLE	LRKELIALQ	DEG_APCC_DBOX_1	236:244	Mutation rewiring degron network	0.2778
p.D234Y	ACH-000868	Lung Cancer	CCLE	LRKELIALQ	DEG_APCC_DBOX_1	236:244	Mutation rewiring degron network	0.2778
p.R237Q	ACH-000991	Colon/Colorectal Cancer	CCLE	LRKELIALQ	DEG_APCC_DBOX_1	236:244	Mutation altering degron motif	0.7329
p.R237Q	SNU-81	large intestine	COSMIC	LRKELIALQ	DEG_APCC_DBOX_1	236:244	Mutation altering degron motif	0.7329
p.L252F	AU565	breast	COSMIC	LRKELIALQ	DEG_APCC_DBOX_1	236:244	Mutation rewiring degron network	0.1111

Kaplan plot for SLMAP in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLMAP

UniProt ID: Q14BN4

Entrez ID: 7871

Protein name: Sarcolemmal membrane-associated protein (Sarcolemmal-associated protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLMAP in