DegronMD

Uniprot ID: Q14BN4

Source protein: Sarcolemmal membrane-associated protein

Source gene: SLMAP

Class: DEG_APCC_DBOX_1

Location: 236:244

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5725

ASA_SCORE: 86.8889

COIL: 0.0169

CONS_SCORE: 0.4633

DSS_SCORE: 0.4216

HELIX: 0.9828

FCONS_SCORE: 1.1364

RIG_SCORE: 0.7935

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A254S	TCGA-A5-A0G2	UCEC	TCGA	LRKELIALQ	DEG_APCC_DBOX_1	0.0556
p.A254S	DO41235	UCEC	ICGC	LRKELIALQ	DEG_APCC_DBOX_1	0.0556
p.E233A	DO233937	GACA	ICGC	LRKELIALQ	DEG_APCC_DBOX_1	0.25
p.S235I	DO228976	LICA	ICGC	LRKELIALQ	DEG_APCC_DBOX_1	0.75
p.N230S	DO229268	THCA	ICGC	LRKELIALQ	DEG_APCC_DBOX_1	0.1667
p.E251G	SIDM00190	Melanoma	GDSC	LRKELIALQ	DEG_APCC_DBOX_1	0.1389
p.E251G	ACH-002097	Skin Cancer	CCLE	LRKELIALQ	DEG_APCC_DBOX_1	0.1389
p.E251G	CP66-MEL	skin	COSMIC	LRKELIALQ	DEG_APCC_DBOX_1	0.1389
p.I241L	SIDM00683	Prostate Carcinoma	GDSC	LRKELIALQ	DEG_APCC_DBOX_1	0.6063
p.I241L	ACH-000977	lymph_node	CCLE	LRKELIALQ	DEG_APCC_DBOX_1	0.6063
p.I241L	LNCaP-Clone-FGC	prostate	COSMIC	LRKELIALQ	DEG_APCC_DBOX_1	0.6063
p.D234H	ACH-000837	Lung Cancer	CCLE	LRKELIALQ	DEG_APCC_DBOX_1	0.2778
p.D234Y	ACH-000868	Lung Cancer	CCLE	LRKELIALQ	DEG_APCC_DBOX_1	0.2778
p.R237Q	ACH-000991	Colon/Colorectal Cancer	CCLE	LRKELIALQ	DEG_APCC_DBOX_1	0.7329
p.R237Q	SNU-81	large_intestine	COSMIC	LRKELIALQ	DEG_APCC_DBOX_1	0.7329
p.L252F	AU565	breast	COSMIC	LRKELIALQ	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14BN4	Sarcolemmal membrane-associated protein	DEG_APCC_DBOX_1	236:244	LRKELIALQ	APC,CDC20,FZR1	0.5725	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons