DegronMD - Q14CW9(ATXN7L3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S277I	TCGA-CD-5798	STAD	TCGA	DSGSSKT	DEG_SCF_TRCP1_1	284:290	Mutation rewiring degron network	0.1389
p.W281L	TCGA-D3-A2JK	SKCM	TCGA	DSGSSKT	DEG_SCF_TRCP1_1	284:290	Mutation blocking phosphorylation signal	0.6944
p.S295C	TCGA-F7-A624	HNSC	TCGA	DSGSSKT	DEG_SCF_TRCP1_1	284:290	Mutation rewiring degron network	0.1944
p.T297M	TCGA-G4-6588	COAD	TCGA	DSGSSKT	DEG_SCF_TRCP1_1	284:290	Mutation rewiring degron network	0.1389
p.D291H	TCGA-OL-A6VO	BRCA	TCGA	DSGSSKT	DEG_SCF_TRCP1_1	284:290	Mutation rewiring degron network	0.3056
p.D284H	DO51213	BRCA	ICGC	DSGSSKT	DEG_SCF_TRCP1_1	284:290	Mutation altering degron motif	0.7688
p.T290M	DO10140	COAD	ICGC	DSGSSKT	DEG_SCF_TRCP1_1	284:290	Mutation altering degron motif	0.8534
p.N293S	DO233286	GACA	ICGC	DSGSSKT	DEG_SCF_TRCP1_1	284:290	Mutation rewiring degron network	0.25
p.S288C	DO44440	HNSC	ICGC	DSGSSKT	DEG_SCF_TRCP1_1	284:290	Mutation altering degron motif	0.643
p.W274L	DO37619	SKCM	ICGC	DSGSSKT	DEG_SCF_TRCP1_1	284:290	Mutation rewiring degron network	0.0556
p.G297S	DO43322	UCEC	ICGC	DSGSSKT	DEG_SCF_TRCP1_1	284:290	Mutation rewiring degron network	0.1389
p.I276L	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	DSGSSKT	DEG_SCF_TRCP1_1	284:290	Mutation rewiring degron network	0.1111
p.I276L	KYSE-450	oesophagus	COSMIC	DSGSSKT	DEG_SCF_TRCP1_1	284:290	Mutation rewiring degron network	0.1111
p.R278Q	SIDM01138	Pancreatic Carcinoma	GDSC	DSGSSKT	DEG_SCF_TRCP1_1	284:290	Mutation blocking phosphorylation signal	0.6111
p.R278Q	PANC-03-27	pancreas	COSMIC	DSGSSKT	DEG_SCF_TRCP1_1	284:290	Mutation blocking phosphorylation signal	0.6111

Kaplan plot for ATXN7L3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ATXN7L3

UniProt ID: Q14CW9

Entrez ID: 56970

Protein name: Ataxin-7-like protein 3 (SAGA-associated factor 11 homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ATXN7L3 in