DegronMD

Uniprot ID: Q14CW9

Source protein: Ataxin-7-like protein 3

Source gene: ATXN7L3

Class: DEG_SCF_TRCP1_1

Location: 284:290

E3 ligase: BTRC

DEGRON score: 0.996

ASA_SCORE: 74.8143

COIL: 0.8886

CONS_SCORE: 0.5257

DSS_SCORE: 0.6501

HELIX: 0.0781

FCONS_SCORE: 1.3039

RIG_SCORE: 0.5284

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S277I	TCGA-CD-5798	STAD	TCGA	DSGSSKT	DEG_SCF_TRCP1_1	0.1389
p.W281L	TCGA-D3-A2JK	SKCM	TCGA	DSGSSKT	DEG_SCF_TRCP1_1	0.6944
p.S295C	TCGA-F7-A624	HNSC	TCGA	DSGSSKT	DEG_SCF_TRCP1_1	0.1944
p.T297M	TCGA-G4-6588	COAD	TCGA	DSGSSKT	DEG_SCF_TRCP1_1	0.1389
p.D291H	TCGA-OL-A6VO	BRCA	TCGA	DSGSSKT	DEG_SCF_TRCP1_1	0.3056
p.D284H	DO51213	BRCA	ICGC	DSGSSKT	DEG_SCF_TRCP1_1	0.7688
p.T290M	DO10140	COAD	ICGC	DSGSSKT	DEG_SCF_TRCP1_1	0.8534
p.N293S	DO233286	GACA	ICGC	DSGSSKT	DEG_SCF_TRCP1_1	0.25
p.S288C	DO44440	HNSC	ICGC	DSGSSKT	DEG_SCF_TRCP1_1	0.643
p.W274L	DO37619	SKCM	ICGC	DSGSSKT	DEG_SCF_TRCP1_1	0.0556
p.G297S	DO43322	UCEC	ICGC	DSGSSKT	DEG_SCF_TRCP1_1	0.1389
p.I276L	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	DSGSSKT	DEG_SCF_TRCP1_1	0.1111
p.I276L	KYSE-450	oesophagus	COSMIC	DSGSSKT	DEG_SCF_TRCP1_1	0.1111
p.R278Q	SIDM01138	Pancreatic Carcinoma	GDSC	DSGSSKT	DEG_SCF_TRCP1_1	0.6111
p.R278Q	PANC-03-27	pancreas	COSMIC	DSGSSKT	DEG_SCF_TRCP1_1	0.6111

DegronMD: protein-targeted degradation, mutation and drug response to degrons