DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DSGSSKT
Uniprot ID:
Q15397
Source protein:
Pumilio homolog 3
Source gene:
PUM3
Class:
DEG_SCF_TRCP1_1
Location:
28:34
E3 ligase:
BTRC
DEGRON score:
0.9928
ASA_SCORE:
90.1429
COIL:
0.9473
CONS_SCORE:
0.2602
DSS_SCORE:
0.6457
HELIX:
0.0273
FCONS_SCORE:
1.0091
RIG_SCORE:
0.5737
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with PUM3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSGSSKT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q14CW9
Ataxin-7-like protein 3
DEG_SCF_TRCP1_1
284:290
DSGSSKT
BTRC
0.996
More...
Q15397
Pumilio homolog 3
DEG_SCF_TRCP1_1
28:34
DSGSSKT
BTRC
0.9928
More...