DegronMD - Q14D04(VEPH1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G424V	TCGA-CV-7245	HNSC	TCGA	RRYSLGQVS	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.25
p.G424V	DO14322	HNSC	ICGC	RRYSLGQVS	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.25
p.A418S	TCGA-CV-A6K2	HNSC	TCGA	RRYSLGQVS	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.0833
p.A418S	DO52079	HNSC	ICGC	RRYSLGQVS	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.0833
p.F444L	TCGA-D1-A103	UCEC	TCGA	RRYSLGQVS	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.0833
p.F444L	DO42312	UCEC	ICGC	RRYSLGQVS	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.0833
p.G419E	TCGA-D6-6516	HNSC	TCGA	RRYSLGQVS	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.1111
p.G419E	DO15623	HNSC	ICGC	RRYSLGQVS	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.1111
p.S425C	TCGA-GC-A3I6	BLCA	TCGA	RRYSLGQVS	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.2778
p.S425C	TCGA-ZF-AA4X	BLCA	TCGA	RRYSLGQVS	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.2778
p.S425C	DO844	BLCA	ICGC	RRYSLGQVS	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.2778
p.S425C	DO219091	BLCA	ICGC	RRYSLGQVS	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.2778
p.S435Y	DO8898	COAD	ICGC	RRYSLGQVS	DEG_APCC_DBOX_1	427:435	Mutation altering degron motif	0.6009
p.R428S	DO233858	GACA	ICGC	RRYSLGQVS	DEG_APCC_DBOX_1	427:435	Mutation altering degron motif	0.7427
p.S420R	DO228926	LICA	ICGC	RRYSLGQVS	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.1389
p.I426V	SIDM01194	Hepatocellular Carcinoma	GDSC	RRYSLGQVS	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.3056
p.I426V	ACH-000420	Liver Cancer	CCLE	RRYSLGQVS	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.3056
p.I426V	SNU-449	liver	COSMIC	RRYSLGQVS	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.3056

Kaplan plot for VEPH1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

VEPH1

UniProt ID: Q14D04

Entrez ID: 79674

Protein name: Ventricular zone-expressed PH domain-containing protein homolog 1 (Protein melted)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for VEPH1 in