DegronMD

Uniprot ID: Q14D04

Source protein: Ventricular zone-expressed PH domain-containing protein homolog 1

Source gene: VEPH1

Class: DEG_APCC_DBOX_1

Location: 427:435

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9993

ASA_SCORE: 79.5222

COIL: 0.7074

CONS_SCORE: 0.3542

DSS_SCORE: 0.4853

HELIX: 0.0743

FCONS_SCORE: 1.0102

RIG_SCORE: 0.7436

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G424V	TCGA-CV-7245	HNSC	TCGA	RRYSLGQVS	DEG_APCC_DBOX_1	0.25
p.G424V	DO14322	HNSC	ICGC	RRYSLGQVS	DEG_APCC_DBOX_1	0.25
p.A418S	TCGA-CV-A6K2	HNSC	TCGA	RRYSLGQVS	DEG_APCC_DBOX_1	0.0833
p.A418S	DO52079	HNSC	ICGC	RRYSLGQVS	DEG_APCC_DBOX_1	0.0833
p.F444L	TCGA-D1-A103	UCEC	TCGA	RRYSLGQVS	DEG_APCC_DBOX_1	0.0833
p.F444L	DO42312	UCEC	ICGC	RRYSLGQVS	DEG_APCC_DBOX_1	0.0833
p.G419E	TCGA-D6-6516	HNSC	TCGA	RRYSLGQVS	DEG_APCC_DBOX_1	0.1111
p.G419E	DO15623	HNSC	ICGC	RRYSLGQVS	DEG_APCC_DBOX_1	0.1111
p.S425C	TCGA-GC-A3I6	BLCA	TCGA	RRYSLGQVS	DEG_APCC_DBOX_1	0.2778
p.S425C	TCGA-ZF-AA4X	BLCA	TCGA	RRYSLGQVS	DEG_APCC_DBOX_1	0.2778
p.S425C	DO844	BLCA	ICGC	RRYSLGQVS	DEG_APCC_DBOX_1	0.2778
p.S425C	DO219091	BLCA	ICGC	RRYSLGQVS	DEG_APCC_DBOX_1	0.2778
p.S435Y	DO8898	COAD	ICGC	RRYSLGQVS	DEG_APCC_DBOX_1	0.6009
p.R428S	DO233858	GACA	ICGC	RRYSLGQVS	DEG_APCC_DBOX_1	0.7427
p.S420R	DO228926	LICA	ICGC	RRYSLGQVS	DEG_APCC_DBOX_1	0.1389
p.I426V	SIDM01194	Hepatocellular Carcinoma	GDSC	RRYSLGQVS	DEG_APCC_DBOX_1	0.3056
p.I426V	ACH-000420	Liver Cancer	CCLE	RRYSLGQVS	DEG_APCC_DBOX_1	0.3056
p.I426V	SNU-449	liver	COSMIC	RRYSLGQVS	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14D04	Ventricular zone-expressed PH domain-containing protein homolog 1	DEG_APCC_DBOX_1	427:435	RRYSLGQVS	APC,CDC20,FZR1	0.9993	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons