DegronMD - Q15020(SART3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P917H	TCGA-AP-A1DK	UCEC	TCGA	GRTQLSLLP	DEG_APCC_DBOX_1	909:917	Mutation altering degron motif	0.6583
p.G904R	TCGA-B5-A3FC	UCEC	TCGA	GRTQLSLLP	DEG_APCC_DBOX_1	909:917	Mutation rewiring degron network	0.1944
p.G904R	SIDM00901	Endometrial Carcinoma	GDSC	GRTQLSLLP	DEG_APCC_DBOX_1	909:917	Mutation rewiring degron network	0.1944
p.G904R	ACH-000940	Endometrial/Uterine Cancer	CCLE	GRTQLSLLP	DEG_APCC_DBOX_1	909:917	Mutation rewiring degron network	0.1944
p.G904R	AN3-CA	endometrium	COSMIC	GRTQLSLLP	DEG_APCC_DBOX_1	909:917	Mutation rewiring degron network	0.1944
p.S924R	TCGA-BS-A0UF	UCEC	TCGA	GRTQLSLLP	DEG_APCC_DBOX_1	909:917	Mutation blocking phosphorylation signal	0.5833
p.S916P	DO227987	COCA	ICGC	GRTQLSLLP	DEG_APCC_DBOX_1	909:917	Mutation altering degron motif	0.6752
p.A903E	DO229006	LICA	ICGC	GRTQLSLLP	DEG_APCC_DBOX_1	909:917	Mutation rewiring degron network	0.1667
p.E911D	DO229257	THCA	ICGC	GRTQLSLLP	DEG_APCC_DBOX_1	909:917	Mutation altering degron motif	0.6758
p.D919N	DO43041	UCEC	ICGC	GRTQLSLLP	DEG_APCC_DBOX_1	909:917	Mutation rewiring degron network	0.2778
p.D919N	DO42504	UCEC	ICGC	GRTQLSLLP	DEG_APCC_DBOX_1	909:917	Mutation rewiring degron network	0.2778
p.D919N	DO41199	UCEC	ICGC	GRTQLSLLP	DEG_APCC_DBOX_1	909:917	Mutation rewiring degron network	0.2778
p.D919N	TOV-21G	ovary	COSMIC	GRTQLSLLP	DEG_APCC_DBOX_1	909:917	Mutation rewiring degron network	0.2778
p.A900V	DO41602	UCEC	ICGC	GRTQLSLLP	DEG_APCC_DBOX_1	909:917	Mutation rewiring degron network	0.0833
p.A906T	SK-OV-3	ovary	COSMIC	GRTQLSLLP	DEG_APCC_DBOX_1	909:917	Mutation rewiring degron network	0.25

Kaplan plot for SART3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SART3

UniProt ID: Q15020

Entrez ID: 9733

Protein name: Squamous cell carcinoma antigen recognized by T-cells 3 (SART-3) (Tat-interacting protein of 110 kDa) (Tip110) (p110 nuclear RNA-binding protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SART3 in