DegronMD

Uniprot ID: Q15020

Source protein: Squamous cell carcinoma antigen recognized by T-cells 3

Source gene: SART3

Class: DEG_APCC_DBOX_1

Location: 909:917

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9989

ASA_SCORE: 74.3111

COIL: 0.7228

CONS_SCORE: 0.4106

DSS_SCORE: 0.6196

HELIX: 0.1693

FCONS_SCORE: 1.1873

RIG_SCORE: 0.7392

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P917H	TCGA-AP-A1DK	UCEC	TCGA	GRTQLSLLP	DEG_APCC_DBOX_1	0.6583
p.G904R	TCGA-B5-A3FC	UCEC	TCGA	GRTQLSLLP	DEG_APCC_DBOX_1	0.1944
p.G904R	SIDM00901	Endometrial Carcinoma	GDSC	GRTQLSLLP	DEG_APCC_DBOX_1	0.1944
p.G904R	ACH-000940	Endometrial/Uterine Cancer	CCLE	GRTQLSLLP	DEG_APCC_DBOX_1	0.1944
p.G904R	AN3-CA	endometrium	COSMIC	GRTQLSLLP	DEG_APCC_DBOX_1	0.1944
p.S924R	TCGA-BS-A0UF	UCEC	TCGA	GRTQLSLLP	DEG_APCC_DBOX_1	0.5833
p.S916P	DO227987	COCA	ICGC	GRTQLSLLP	DEG_APCC_DBOX_1	0.6752
p.A903E	DO229006	LICA	ICGC	GRTQLSLLP	DEG_APCC_DBOX_1	0.1667
p.E911D	DO229257	THCA	ICGC	GRTQLSLLP	DEG_APCC_DBOX_1	0.6758
p.D919N	DO43041	UCEC	ICGC	GRTQLSLLP	DEG_APCC_DBOX_1	0.2778
p.D919N	DO42504	UCEC	ICGC	GRTQLSLLP	DEG_APCC_DBOX_1	0.2778
p.D919N	DO41199	UCEC	ICGC	GRTQLSLLP	DEG_APCC_DBOX_1	0.2778
p.D919N	TOV-21G	ovary	COSMIC	GRTQLSLLP	DEG_APCC_DBOX_1	0.2778
p.A900V	DO41602	UCEC	ICGC	GRTQLSLLP	DEG_APCC_DBOX_1	0.0833
p.A906T	SK-OV-3	ovary	COSMIC	GRTQLSLLP	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15020	Squamous cell carcinoma antigen recognized by T-cells 3	DEG_APCC_DBOX_1	909:917	GRTQLSLLP	APC,CDC20,FZR1	0.9989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons