DegronMD - Q15051(IQCB1)

IQCB1

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E388D	TCGA-2W-A8YY	CESC	TCGA	IQKHWRGYRER	SCF_FBXL2	394:404	Mutation rewiring degron network	0.1667
p.E388D	DO223732	CESC	ICGC	IQKHWRGYRER	SCF_FBXL2	394:404	Mutation rewiring degron network	0.1667
p.R384W	TCGA-G2-A2EJ	BLCA	TCGA	IQKHWRGYRER	SCF_FBXL2	394:404	Mutation rewiring degron network	0.0556
p.R384W	DO554	BLCA	ICGC	IQKHWRGYRER	SCF_FBXL2	394:404	Mutation rewiring degron network	0.0556
p.I393N	DO234285	ESAD	ICGC	IQKHWRGYRER	SCF_FBXL2	394:404	Mutation rewiring degron network	0.3056
p.H408Q	DO229031	LICA	ICGC	IQKHWRGYRER	SCF_FBXL2	394:404	Mutation rewiring degron network	0.2222
p.H397Y	SIDM00352	Ovarian Carcinoma	GDSC	IQKHWRGYRER	SCF_FBXL2	394:404	Mutation altering degron motif	0.6118
p.H397Y	ACH-000719	Ovarian Cancer	CCLE	IQKHWRGYRER	SCF_FBXL2	394:404	Mutation altering degron motif	0.6118
p.H397Y	RMG-I	ovary	COSMIC	IQKHWRGYRER	SCF_FBXL2	394:404	Mutation altering degron motif	0.6118
p.R384Q	SIDM00160	Biliary Tract Carcinoma	GDSC	IQKHWRGYRER	SCF_FBXL2	394:404	Mutation rewiring degron network	0.0556
p.R384Q	ACH-000377	Bile Duct Cancer	CCLE	IQKHWRGYRER	SCF_FBXL2	394:404	Mutation rewiring degron network	0.0556
p.S409F	OVCAR-5	ovary	COSMIC	IQKHWRGYRER	SCF_FBXL2	394:404	Mutation rewiring degron network	0.1944
p.V412A	A172	central nervous system	COSMIC	IQKHWRGYRER	SCF_FBXL2	394:404	Mutation rewiring degron network	0.1111

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*NOTE: the Kaplan plots were collected from OncoLnc