DegronMD

Uniprot ID: Q15051

Source protein: IQ calmodulin-binding motif-containing protein 1

Source gene: IQCB1

Class: SCF_FBXL2

Location: 394:404

E3 ligase: FBXL2

DEGRON score: 0.8526

ASA_SCORE: 73.3273

COIL: 0.0134

CONS_SCORE: 0.7378

DSS_SCORE: 0.3218

HELIX: 0.9869

FCONS_SCORE: 1.355

RIG_SCORE: 0.8102

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E388D	TCGA-2W-A8YY	CESC	TCGA	IQKHWRGYRER	SCF_FBXL2	0.1667
p.E388D	DO223732	CESC	ICGC	IQKHWRGYRER	SCF_FBXL2	0.1667
p.R384W	TCGA-G2-A2EJ	BLCA	TCGA	IQKHWRGYRER	SCF_FBXL2	0.0556
p.R384W	DO554	BLCA	ICGC	IQKHWRGYRER	SCF_FBXL2	0.0556
p.I393N	DO234285	ESAD	ICGC	IQKHWRGYRER	SCF_FBXL2	0.3056
p.H408Q	DO229031	LICA	ICGC	IQKHWRGYRER	SCF_FBXL2	0.2222
p.H397Y	SIDM00352	Ovarian Carcinoma	GDSC	IQKHWRGYRER	SCF_FBXL2	0.6118
p.H397Y	ACH-000719	Ovarian Cancer	CCLE	IQKHWRGYRER	SCF_FBXL2	0.6118
p.H397Y	RMG-I	ovary	COSMIC	IQKHWRGYRER	SCF_FBXL2	0.6118
p.R384Q	SIDM00160	Biliary Tract Carcinoma	GDSC	IQKHWRGYRER	SCF_FBXL2	0.0556
p.R384Q	ACH-000377	Bile Duct Cancer	CCLE	IQKHWRGYRER	SCF_FBXL2	0.0556
p.S409F	OVCAR-5	ovary	COSMIC	IQKHWRGYRER	SCF_FBXL2	0.1944
p.V412A	A172	central_nervous_system	COSMIC	IQKHWRGYRER	SCF_FBXL2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15051	IQ calmodulin-binding motif-containing protein 1	SCF_FBXL2	394:404	IQKHWRGYRER	FBXL2	0.8526	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons