DegronMD - Q15057(ACAP2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G388E	TCGA-BS-A0UV	UCEC	TCGA	DSGNES	DEG_SCF_TRCP1_1	386:391	Mutation altering degron motif	0.7199
p.G388E	DO222762	COCA	ICGC	DSGNES	DEG_SCF_TRCP1_1	386:391	Mutation altering degron motif	0.7199
p.G388E	DO42793	UCEC	ICGC	DSGNES	DEG_SCF_TRCP1_1	386:391	Mutation altering degron motif	0.7199
p.K376N	TCGA-CG-5728	STAD	TCGA	DSGNES	DEG_SCF_TRCP1_1	386:391	Mutation substituting flanking lysine	0.1667
p.K376N	DO38619	STAD	ICGC	DSGNES	DEG_SCF_TRCP1_1	386:391	Mutation substituting flanking lysine	0.1667
p.E393D	TCGA-D1-A16X	UCEC	TCGA	DSGNES	DEG_SCF_TRCP1_1	386:391	Mutation rewiring degron network	0.2778
p.E393D	DO41799	UCEC	ICGC	DSGNES	DEG_SCF_TRCP1_1	386:391	Mutation rewiring degron network	0.2778
p.A401V	TCGA-D5-6536	COAD	TCGA	DSGNES	DEG_SCF_TRCP1_1	386:391	Mutation rewiring degron network	0.0556
p.A401V	DO8200	COAD	ICGC	DSGNES	DEG_SCF_TRCP1_1	386:391	Mutation rewiring degron network	0.0556
p.S391F	TCGA-EK-A2RC	CESC	TCGA	DSGNES	DEG_SCF_TRCP1_1	386:391	Mutation altering degron motif	0.7982
p.S391F	DO49945	CESC	ICGC	DSGNES	DEG_SCF_TRCP1_1	386:391	Mutation altering degron motif	0.7982
p.P380L	DO222837	MELA	ICGC	DSGNES	DEG_SCF_TRCP1_1	386:391	Mutation rewiring degron network	0.1667
p.P380Q	DO229259	THCA	ICGC	DSGNES	DEG_SCF_TRCP1_1	386:391	Mutation rewiring degron network	0.1667
p.K397N	SIDM00742	Non-Small Cell Lung Carcinoma	GDSC	DSGNES	DEG_SCF_TRCP1_1	386:391	Mutation substituting flanking lysine	0.2778
p.K397N	ACH-000021	Lung Cancer	CCLE	DSGNES	DEG_SCF_TRCP1_1	386:391	Mutation substituting flanking lysine	0.2778
p.K397N	NCI-H1693	lung	COSMIC	DSGNES	DEG_SCF_TRCP1_1	386:391	Mutation substituting flanking lysine	0.2778
p.L395F	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	DSGNES	DEG_SCF_TRCP1_1	386:391	Mutation rewiring degron network	0.2222
p.L395F	ACH-000563	Lung Cancer	CCLE	DSGNES	DEG_SCF_TRCP1_1	386:391	Mutation rewiring degron network	0.2222
p.L395F	EBC-1	lung	COSMIC	DSGNES	DEG_SCF_TRCP1_1	386:391	Mutation rewiring degron network	0.2222
p.G388V	SIDM00168	Head and Neck Carcinoma	GDSC	DSGNES	DEG_SCF_TRCP1_1	386:391	Mutation altering degron motif	0.7532
p.G388V	ACH-000549	Head and Neck Cancer	CCLE	DSGNES	DEG_SCF_TRCP1_1	386:391	Mutation altering degron motif	0.7532
p.K396N	NCI-H1693	lung	COSMIC	DSGNES	DEG_SCF_TRCP1_1	386:391	Mutation rewiring degron network	0.1944
p.L394F	EBC-1	lung	COSMIC	DSGNES	DEG_SCF_TRCP1_1	386:391	Mutation substituting flanking lysine	0.3611

Kaplan plot for ACAP2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ACAP2

UniProt ID: Q15057

Entrez ID: 23527

Protein name: Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 (Centaurin-beta-2) (Cnt-b2)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ACAP2 in