DegronMD

Uniprot ID: Q15057

Source protein: Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2

Source gene: ACAP2

Class: DEG_SCF_TRCP1_1

Location: 386:391

E3 ligase: BTRC

DEGRON score: 0.8438

ASA_SCORE: 79.2333

COIL: 0.6335

CONS_SCORE: 0.3105

DSS_SCORE: 0.5991

HELIX: 0.3448

FCONS_SCORE: 1.0711

RIG_SCORE: 0.6063

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G388E	TCGA-BS-A0UV	UCEC	TCGA	DSGNES	DEG_SCF_TRCP1_1	0.7199
p.G388E	DO222762	COCA	ICGC	DSGNES	DEG_SCF_TRCP1_1	0.7199
p.G388E	DO42793	UCEC	ICGC	DSGNES	DEG_SCF_TRCP1_1	0.7199
p.K376N	TCGA-CG-5728	STAD	TCGA	DSGNES	DEG_SCF_TRCP1_1	0.1667
p.K376N	DO38619	STAD	ICGC	DSGNES	DEG_SCF_TRCP1_1	0.1667
p.E393D	TCGA-D1-A16X	UCEC	TCGA	DSGNES	DEG_SCF_TRCP1_1	0.2778
p.E393D	DO41799	UCEC	ICGC	DSGNES	DEG_SCF_TRCP1_1	0.2778
p.A401V	TCGA-D5-6536	COAD	TCGA	DSGNES	DEG_SCF_TRCP1_1	0.0556
p.A401V	DO8200	COAD	ICGC	DSGNES	DEG_SCF_TRCP1_1	0.0556
p.S391F	TCGA-EK-A2RC	CESC	TCGA	DSGNES	DEG_SCF_TRCP1_1	0.7982
p.S391F	DO49945	CESC	ICGC	DSGNES	DEG_SCF_TRCP1_1	0.7982
p.P380L	DO222837	MELA	ICGC	DSGNES	DEG_SCF_TRCP1_1	0.1667
p.P380Q	DO229259	THCA	ICGC	DSGNES	DEG_SCF_TRCP1_1	0.1667
p.K397N	SIDM00742	Non-Small Cell Lung Carcinoma	GDSC	DSGNES	DEG_SCF_TRCP1_1	0.2778
p.K397N	ACH-000021	Lung Cancer	CCLE	DSGNES	DEG_SCF_TRCP1_1	0.2778
p.K397N	NCI-H1693	lung	COSMIC	DSGNES	DEG_SCF_TRCP1_1	0.2778
p.L395F	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	DSGNES	DEG_SCF_TRCP1_1	0.2222
p.L395F	ACH-000563	Lung Cancer	CCLE	DSGNES	DEG_SCF_TRCP1_1	0.2222
p.L395F	EBC-1	lung	COSMIC	DSGNES	DEG_SCF_TRCP1_1	0.2222
p.G388V	SIDM00168	Head and Neck Carcinoma	GDSC	DSGNES	DEG_SCF_TRCP1_1	0.7532
p.G388V	ACH-000549	Head and Neck Cancer	CCLE	DSGNES	DEG_SCF_TRCP1_1	0.7532
p.K396N	NCI-H1693	lung	COSMIC	DSGNES	DEG_SCF_TRCP1_1	0.1944
p.L394F	EBC-1	lung	COSMIC	DSGNES	DEG_SCF_TRCP1_1	0.3611

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15057	Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2	DEG_SCF_TRCP1_1	386:391	DSGNES	BTRC	0.8438	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons