WDR43
UniProt ID: Q15061
Entrez ID: 23160
Protein name: WD repeat-containing protein 43 (U3 small nucleolar RNA-associated protein 5 homolog)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Ribosome biogenesis factor that coordinates hyperactive transcription and ribogenesis (PubMed:17699751). Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (PubMed:17699751). Essential for stem cell pluripoten...
FUNCTION: Ribosome biogenesis factor that coordinates hyperactive transcription and ribogenesis (PubMed:17699751). Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (PubMed:17699751). Essential for stem cell pluripotency and embryonic development. In the nucleoplasm, recruited by promoter-associated/nascent transcripts and transcription to active promoters where it facilitates releases of elongation factor P-TEFb and paused RNA polymerase II to allow transcription elongation and maintain high-level expression of its targets genes (By similarity). {ECO:0000250|UniProtKB:Q6ZQL4, ECO:0000269|PubMed:17699751}.
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GO - Biological processes (BP):
positive regulation of rRNA processing [GO:2000234]; positive regulation of transcription by RNA polymerase I [GO:0045943]; regulation of stem cell population maintenance [GO:2000036]; regulation of transcription elongation from RNA polymerase II promoter [GO:0034243]; rRNA processing [GO:0006364]...
positive regulation of rRNA processing [GO:2000234]; positive regulation of transcription by RNA polymerase I [GO:0045943]; regulation of stem cell population maintenance [GO:2000036]; regulation of transcription elongation from RNA polymerase II promoter [GO:0034243]; rRNA processing [GO:0006364]
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GO - Molecular function (MF):
RNA binding [GO:0003723]; RNA polymerase II complex binding [GO:0000993]; transcription elongation regulator activity [GO:0003711]...
RNA binding [GO:0003723]; RNA polymerase II complex binding [GO:0000993]; transcription elongation regulator activity [GO:0003711]
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GO - Cellular component (CC):
chromatin [GO:0000785]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]...
chromatin [GO:0000785]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]
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WDR43
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Kaplan plot for WDR43 in
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*NOTE: the Kaplan plots were collected from OncoLnc