DegronMD

Uniprot ID: Q15061

Source protein: WD repeat-containing protein 43

Source gene: WDR43

Class: DEG_Kelch_Keap1_1

Location: 647:652

E3 ligase: KEAP1

DEGRON score: 0.998

ASA_SCORE: 116.1167

COIL: 0.9263

CONS_SCORE: 0.4243

DSS_SCORE: 0.9184

HELIX: 0.066

FCONS_SCORE: 1.2812

RIG_SCORE: 0.5569

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E652K	TCGA-CR-7364	HNSC	TCGA	DEENGE	DEG_Kelch_Keap1_1	0.7022
p.E652K	DO15679	HNSC	ICGC	DEENGE	DEG_Kelch_Keap1_1	0.7022
p.A643S	DO229009	LICA	ICGC	DEENGE	DEG_Kelch_Keap1_1	0.2222
p.A643V	DO222402	MELA	ICGC	DEENGE	DEG_Kelch_Keap1_1	0.2222
p.R654T	ACH-000548	Head and Neck Cancer	CCLE	DEENGE	DEG_Kelch_Keap1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15061	WD repeat-containing protein 43	DEG_Kelch_Keap1_1	647:652	DEENGE	KEAP1	0.998	More...
Q9UHG0	Doublecortin domain-containing protein 2	DEG_Kelch_Keap1_1	409:414	DEENGE	KEAP1	0.6337	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons