DegronMD

Uniprot ID: Q9UHG0

Source protein: Doublecortin domain-containing protein 2

Source gene: DCDC2

Class: DEG_Kelch_Keap1_1

Location: 409:414

E3 ligase: KEAP1

DEGRON score: 0.6337

ASA_SCORE: 99.6

COIL: 0.6753

CONS_SCORE: 0.6845

DSS_SCORE: 0.7204

HELIX: 0.3047

FCONS_SCORE: 1.0174

RIG_SCORE: 0.6532

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E415K	TCGA-17-Z014	LUAD	TCGA	DEENGE	DEG_Kelch_Keap1_1	0.3056
p.R400C	TCGA-19-5956	GBM	TCGA	DEENGE	DEG_Kelch_Keap1_1	0.0833
p.R400C	TCGA-BR-8361	STAD	TCGA	DEENGE	DEG_Kelch_Keap1_1	0.0833
p.G406R	TCGA-77-8153	LUSC	TCGA	DEENGE	DEG_Kelch_Keap1_1	0.25
p.D409N	TCGA-AX-A2HC	UCEC	TCGA	DEENGE	DEG_Kelch_Keap1_1	0.5821
p.A402S	TCGA-CV-A461	HNSC	TCGA	DEENGE	DEG_Kelch_Keap1_1	0.1389
p.R400H	TCGA-D1-A17D	UCEC	TCGA	DEENGE	DEG_Kelch_Keap1_1	0.0833
p.R400H	TCGA-XK-AAIW	PRAD	TCGA	DEENGE	DEG_Kelch_Keap1_1	0.0833
p.R400H	SIDM01263	T-Lymphoblastic Leukemia	GDSC	DEENGE	DEG_Kelch_Keap1_1	0.0833
p.E411D	TCGA-E7-A97P	BLCA	TCGA	DEENGE	DEG_Kelch_Keap1_1	0.5647
p.T408S	ACH-001857	Bile Duct Cancer	CCLE	DEENGE	DEG_Kelch_Keap1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15061	WD repeat-containing protein 43	DEG_Kelch_Keap1_1	647:652	DEENGE	KEAP1	0.998	More...
Q9UHG0	Doublecortin domain-containing protein 2	DEG_Kelch_Keap1_1	409:414	DEENGE	KEAP1	0.6337	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons