DegronMD - Q9UHG0(DCDC2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E415K	TCGA-17-Z014	LUAD	TCGA	DEENGE	DEG_Kelch_Keap1_1	409:414	Mutation rewiring degron network	0.3056
p.R400C	TCGA-19-5956	GBM	TCGA	DEENGE	DEG_Kelch_Keap1_1	409:414	Mutation rewiring degron network	0.0833
p.R400C	TCGA-BR-8361	STAD	TCGA	DEENGE	DEG_Kelch_Keap1_1	409:414	Mutation rewiring degron network	0.0833
p.G406R	TCGA-77-8153	LUSC	TCGA	DEENGE	DEG_Kelch_Keap1_1	409:414	Mutation rewiring degron network	0.25
p.D409N	TCGA-AX-A2HC	UCEC	TCGA	DEENGE	DEG_Kelch_Keap1_1	409:414	Mutation altering degron motif	0.5821
p.A402S	TCGA-CV-A461	HNSC	TCGA	DEENGE	DEG_Kelch_Keap1_1	409:414	Mutation rewiring degron network	0.1389
p.R400H	TCGA-D1-A17D	UCEC	TCGA	DEENGE	DEG_Kelch_Keap1_1	409:414	Mutation rewiring degron network	0.0833
p.R400H	TCGA-XK-AAIW	PRAD	TCGA	DEENGE	DEG_Kelch_Keap1_1	409:414	Mutation rewiring degron network	0.0833
p.R400H	SIDM01263	T-Lymphoblastic Leukemia	GDSC	DEENGE	DEG_Kelch_Keap1_1	409:414	Mutation rewiring degron network	0.0833
p.E411D	TCGA-E7-A97P	BLCA	TCGA	DEENGE	DEG_Kelch_Keap1_1	409:414	Mutation altering degron motif	0.5647
p.T408S	ACH-001857	Bile Duct Cancer	CCLE	DEENGE	DEG_Kelch_Keap1_1	409:414	Mutation rewiring degron network	0.3056

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons