DegronMD - Q15111(PLCL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1078H	TCGA-AX-A1C7	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	1067:1071	Mutation rewiring degron network	0.1389
p.R1078H	TCGA-CV-7435	HNSC	TCGA	APSSS	DEG_SPOP_SBC_1	1067:1071	Mutation rewiring degron network	0.1389
p.R1078H	TCGA-E7-A677	BLCA	TCGA	APSSS	DEG_SPOP_SBC_1	1067:1071	Mutation rewiring degron network	0.1389
p.R1078H	DO44033	BLCA	ICGC	APSSS	DEG_SPOP_SBC_1	1067:1071	Mutation rewiring degron network	0.1389
p.R1078H	DO14918	HNSC	ICGC	APSSS	DEG_SPOP_SBC_1	1067:1071	Mutation rewiring degron network	0.1389
p.R1078H	DO41115	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	1067:1071	Mutation rewiring degron network	0.1389
p.P1068H	TCGA-BR-4292	STAD	TCGA	APSSS	DEG_SPOP_SBC_1	1067:1071	Mutation altering degron motif	0.6583
p.P1068H	DO38495	STAD	ICGC	APSSS	DEG_SPOP_SBC_1	1067:1071	Mutation altering degron motif	0.6583
p.P528Q	TCGA-CD-8530	STAD	TCGA	NKLYTEAP	CBL_PTK	513:520	Mutation rewiring degron network	0.1111
p.P528Q	DO47793	STAD	ICGC	NKLYTEAP	CBL_PTK	513:520	Mutation rewiring degron network	0.1111
p.G1063V	TCGA-CV-A45Z	HNSC	TCGA	APSSS	DEG_SPOP_SBC_1	1067:1071	Mutation rewiring degron network	0.2222
p.G1063V	DO52064	HNSC	ICGC	APSSS	DEG_SPOP_SBC_1	1067:1071	Mutation rewiring degron network	0.2222
p.S529L	TCGA-DK-AA71	BLCA	TCGA	NKLYTEAP	CBL_PTK	513:520	Mutation rewiring degron network	0.0833
p.S529L	DO219010	BLCA	ICGC	NKLYTEAP	CBL_PTK	513:520	Mutation rewiring degron network	0.0833
p.S1065R	TCGA-VQ-AA6J	STAD	TCGA	APSSS	DEG_SPOP_SBC_1	1067:1071	Mutation rewiring degron network	0.2778
p.S1065R	DO51802	STAD	ICGC	APSSS	DEG_SPOP_SBC_1	1067:1071	Mutation rewiring degron network	0.2778
p.P1068R	DO222660	BTCA	ICGC	APSSS	DEG_SPOP_SBC_1	1067:1071	Mutation altering degron motif	0.6401
p.S1061F	DO230312	COCA	ICGC	APSSS	DEG_SPOP_SBC_1	1067:1071	Mutation rewiring degron network	0.1667
p.C1059Y	DO230335	COCA	ICGC	APSSS	DEG_SPOP_SBC_1	1067:1071	Mutation rewiring degron network	0.1111
p.V510I	DO234340	ESAD	ICGC	NKLYTEAP	CBL_PTK	513:520	Mutation rewiring degron network	0.25
p.C1062R	DO23504	LINC	ICGC	APSSS	DEG_SPOP_SBC_1	1067:1071	Mutation rewiring degron network	0.1944
p.M503I	DO229446	SKCA	ICGC	NKLYTEAP	CBL_PTK	513:520	Mutation rewiring degron network	0.0556
p.T517I	SIDM00373	Endometrial Carcinoma	GDSC	NKLYTEAP	CBL_PTK	513:520	Mutation altering degron motif	0.7078
p.T517I	ACH-000974	Endometrial/Uterine Cancer	CCLE	NKLYTEAP	CBL_PTK	513:520	Mutation altering degron motif	0.7078
p.T517S	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	NKLYTEAP	CBL_PTK	513:520	Mutation altering degron motif	0.6005
p.T517S	ACH-000438	Lung Cancer	CCLE	NKLYTEAP	CBL_PTK	513:520	Mutation altering degron motif	0.6005
p.T517S	LU-65	lung	COSMIC	NKLYTEAP	CBL_PTK	513:520	Mutation altering degron motif	0.6005
p.S1069N	ACH-001030	Bone Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	1067:1071	Mutation altering degron motif	0.7069
p.M527V	BT-474	breast	COSMIC	NKLYTEAP	CBL_PTK	513:520	Mutation rewiring degron network	0.1389
p.S529I	HT-115	large intestine	COSMIC	NKLYTEAP	CBL_PTK	513:520	Mutation rewiring degron network	0.0833
p.E1081K	NCI-H2052	pleura	COSMIC	APSSS	DEG_SPOP_SBC_1	1067:1071	Mutation rewiring degron network	0.0556

Kaplan plot for PLCL1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PLCL1

UniProt ID: Q15111

Entrez ID: 5334

Protein name: Inactive phospholipase C-like protein 1 (PLC-L1) (Phospholipase C-deleted in lung carcinoma) (Phospholipase C-related but catalytically inactive protein) (PRIP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PLCL1 in