DegronMD

Uniprot ID: Q15111

Source protein: Inactive phospholipase C-like protein 1

Source gene: PLCL1

Class: CBL_PTK

Location: 513:520

E3 ligase: CBL

DEGRON score: 0.8765

ASA_SCORE: 81.275

COIL: 0.808

CONS_SCORE: 0.4091

DSS_SCORE: 0.2758

HELIX: 0.0763

FCONS_SCORE: 0.9718

RIG_SCORE: 0.7691

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T517I	SIDM00373	Endometrial Carcinoma	GDSC	NKLYTEAP	CBL_PTK	0.7078
p.T517I	ACH-000974	Endometrial/Uterine Cancer	CCLE	NKLYTEAP	CBL_PTK	0.7078
p.T517S	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	NKLYTEAP	CBL_PTK	0.6005
p.T517S	ACH-000438	Lung Cancer	CCLE	NKLYTEAP	CBL_PTK	0.6005
p.T517S	LU-65	lung	COSMIC	NKLYTEAP	CBL_PTK	0.6005
p.V510I	DO234340	ESAD	ICGC	NKLYTEAP	CBL_PTK	0.25
p.M527V	BT-474	breast	COSMIC	NKLYTEAP	CBL_PTK	0.1389
p.P528Q	TCGA-CD-8530	STAD	TCGA	NKLYTEAP	CBL_PTK	0.1111
p.P528Q	DO47793	STAD	ICGC	NKLYTEAP	CBL_PTK	0.1111
p.S529L	TCGA-DK-AA71	BLCA	TCGA	NKLYTEAP	CBL_PTK	0.0833
p.S529L	DO219010	BLCA	ICGC	NKLYTEAP	CBL_PTK	0.0833
p.S529I	HT-115	large_intestine	COSMIC	NKLYTEAP	CBL_PTK	0.0833
p.M503I	DO229446	SKCA	ICGC	NKLYTEAP	CBL_PTK	0.0556

Showing 1 to 13 of 13 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15111	Inactive phospholipase C-like protein 1	CBL_PTK	513:520	NKLYTEAP	CBL	0.8765	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons