DegronMD - Q15118(PDK1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L325F	TCGA-17-Z022	LUAD	TCGA	NYMYSTAP	CBL_PTK	333:340	Mutation rewiring degron network	0.1111
p.V323I	TCGA-A5-A2K3	UCEC	TCGA	NYMYSTAP	CBL_PTK	333:340	Mutation rewiring degron network	0.0556
p.V323I	DO43899	UCEC	ICGC	NYMYSTAP	CBL_PTK	333:340	Mutation rewiring degron network	0.0556
p.R343H	TCGA-BG-A222	UCEC	TCGA	NYMYSTAP	CBL_PTK	333:340	Mutation rewiring degron network	0.25
p.R343H	DO42977	UCEC	ICGC	NYMYSTAP	CBL_PTK	333:340	Mutation rewiring degron network	0.25
p.R343H	ACH-001049	Lung Cancer	CCLE	NYMYSTAP	CBL_PTK	333:340	Mutation rewiring degron network	0.25
p.R343H	CPC-N	lung	COSMIC	NYMYSTAP	CBL_PTK	333:340	Mutation rewiring degron network	0.25
p.P324S	TCGA-EE-A2MJ	SKCM	TCGA	NYMYSTAP	CBL_PTK	333:340	Mutation rewiring degron network	0.0833
p.P324S	DO38099	SKCM	ICGC	NYMYSTAP	CBL_PTK	333:340	Mutation rewiring degron network	0.0833
p.A349T	TCGA-IR-A3LK	CESC	TCGA	NYMYSTAP	CBL_PTK	333:340	Mutation rewiring degron network	0.0833
p.A349T	DO44299	CESC	ICGC	NYMYSTAP	CBL_PTK	333:340	Mutation rewiring degron network	0.0833
p.A349T	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	NYMYSTAP	CBL_PTK	333:340	Mutation rewiring degron network	0.0833
p.A349T	SNU-1040	large intestine	COSMIC	NYMYSTAP	CBL_PTK	333:340	Mutation rewiring degron network	0.0833
p.A349T	DG-75	haematopoietic and lymphoid tissue	COSMIC	NYMYSTAP	CBL_PTK	333:340	Mutation rewiring degron network	0.0833
p.E345Q	TCGA-Q1-A73O	CESC	TCGA	NYMYSTAP	CBL_PTK	333:340	Mutation rewiring degron network	0.1944
p.E345Q	DO51612	CESC	ICGC	NYMYSTAP	CBL_PTK	333:340	Mutation rewiring degron network	0.1944
p.T338S	TCGA-XK-AAJT	PRAD	TCGA	NYMYSTAP	CBL_PTK	333:340	Mutation altering degron motif	0.7116
p.T338S	DO51414	PRAD	ICGC	NYMYSTAP	CBL_PTK	333:340	Mutation altering degron motif	0.7116
p.R330I	DO233737	GACA	ICGC	NYMYSTAP	CBL_PTK	333:340	Mutation rewiring degron network	0.25
p.R343L	DO229031	LICA	ICGC	NYMYSTAP	CBL_PTK	333:340	Mutation rewiring degron network	0.25
p.T326M	SIDM00656	Burkitt's Lymphoma	GDSC	NYMYSTAP	CBL_PTK	333:340	Mutation rewiring degron network	0.1389
p.R348H	KM12	large intestine	COSMIC	NYMYSTAP	CBL_PTK	333:340	Mutation rewiring degron network	0.1111

Kaplan plot for PDK1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PDK1

UniProt ID: Q15118

Entrez ID: 5163

Protein name: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for PDK1 in