DegronMD

Uniprot ID: Q15118

Source protein: [Pyruvate dehydrogenase

Source gene: PDK1

Class: CBL_PTK

Location: 333:340

E3 ligase: CBL

DEGRON score: 0.9453

ASA_SCORE: 59.3

COIL: 0.6313

CONS_SCORE: 0.6746

DSS_SCORE: 0.2643

HELIX: 0.1588

FCONS_SCORE: 1.3477

RIG_SCORE: 0.8063

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L325F	TCGA-17-Z022	LUAD	TCGA	NYMYSTAP	CBL_PTK	0.1111
p.V323I	TCGA-A5-A2K3	UCEC	TCGA	NYMYSTAP	CBL_PTK	0.0556
p.V323I	DO43899	UCEC	ICGC	NYMYSTAP	CBL_PTK	0.0556
p.R343H	TCGA-BG-A222	UCEC	TCGA	NYMYSTAP	CBL_PTK	0.25
p.R343H	DO42977	UCEC	ICGC	NYMYSTAP	CBL_PTK	0.25
p.R343H	ACH-001049	Lung Cancer	CCLE	NYMYSTAP	CBL_PTK	0.25
p.R343H	CPC-N	lung	COSMIC	NYMYSTAP	CBL_PTK	0.25
p.P324S	TCGA-EE-A2MJ	SKCM	TCGA	NYMYSTAP	CBL_PTK	0.0833
p.P324S	DO38099	SKCM	ICGC	NYMYSTAP	CBL_PTK	0.0833
p.A349T	TCGA-IR-A3LK	CESC	TCGA	NYMYSTAP	CBL_PTK	0.0833
p.A349T	DO44299	CESC	ICGC	NYMYSTAP	CBL_PTK	0.0833
p.A349T	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	NYMYSTAP	CBL_PTK	0.0833
p.A349T	SNU-1040	large_intestine	COSMIC	NYMYSTAP	CBL_PTK	0.0833
p.A349T	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	NYMYSTAP	CBL_PTK	0.0833
p.E345Q	TCGA-Q1-A73O	CESC	TCGA	NYMYSTAP	CBL_PTK	0.1944
p.E345Q	DO51612	CESC	ICGC	NYMYSTAP	CBL_PTK	0.1944
p.T338S	TCGA-XK-AAJT	PRAD	TCGA	NYMYSTAP	CBL_PTK	0.7116
p.T338S	DO51414	PRAD	ICGC	NYMYSTAP	CBL_PTK	0.7116
p.R330I	DO233737	GACA	ICGC	NYMYSTAP	CBL_PTK	0.25
p.R343L	DO229031	LICA	ICGC	NYMYSTAP	CBL_PTK	0.25
p.T326M	SIDM00656	Burkitt's Lymphoma	GDSC	NYMYSTAP	CBL_PTK	0.1389
p.R348H	KM12	large_intestine	COSMIC	NYMYSTAP	CBL_PTK	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15118	[Pyruvate dehydrogenase	CBL_PTK	333:340	NYMYSTAP	CBL	0.9453	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons