DegronMD - Q15124(PGM5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G532S	TCGA-06-0749	GBM	TCGA	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation rewiring degron network	0.1111
p.G532S	DO12694	GBM	ICGC	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation rewiring degron network	0.1111
p.G532S	SIDM01664	Prostate Carcinoma	GDSC	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation rewiring degron network	0.1111
p.T518S	TCGA-58-A46M	LUSC	TCGA	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation rewiring degron network	0.3056
p.T518S	DO45485	LUSC	ICGC	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation rewiring degron network	0.3056
p.E527K	TCGA-B5-A3FC	UCEC	TCGA	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation rewiring degron network	0.25
p.E527K	DO41871	UCEC	ICGC	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation rewiring degron network	0.25
p.H533L	TCGA-BA-A6DA	HNSC	TCGA	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation rewiring degron network	0.0833
p.H533L	DO44448	HNSC	ICGC	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation rewiring degron network	0.0833
p.R516W	TCGA-BR-8680	STAD	TCGA	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation rewiring degron network	0.25
p.R516W	TCGA-EI-6917	READ	TCGA	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation rewiring degron network	0.25
p.R516W	DO36881	READ	ICGC	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation rewiring degron network	0.25
p.R516W	DO47769	STAD	ICGC	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation rewiring degron network	0.25
p.P530S	TCGA-EE-A3AA	SKCM	TCGA	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation rewiring degron network	0.1667
p.P530S	DO222632	MELA	ICGC	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation rewiring degron network	0.1667
p.P530S	DO37571	SKCM	ICGC	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation rewiring degron network	0.1667
p.A523T	TCGA-VR-A8EQ	ESCA	TCGA	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation altering degron motif	0.6028
p.A523T	DO46591	OV	ICGC	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation altering degron motif	0.6028
p.G532C	DO228948	LICA	ICGC	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation rewiring degron network	0.1111
p.G532C	DO229031	LICA	ICGC	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation rewiring degron network	0.1111
p.D529Y	DO228952	LICA	ICGC	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation rewiring degron network	0.1944
p.G514C	DO229019	LICA	ICGC	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation rewiring degron network	0.1944
p.G514C	DO229034	LICA	ICGC	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation rewiring degron network	0.1944
p.S525N	DO222843	MELA	ICGC	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation blocking phosphorylation signal	0.75
p.S513R	SIDM00221	Melanoma	GDSC	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation blocking phosphorylation signal	0.6111
p.R520I	SIDM00760	Small Cell Lung Carcinoma	GDSC	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation altering degron motif	0.6991
p.R520I	ACH-000729	Lung Cancer	CCLE	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation altering degron motif	0.6991
p.R520I	NCI-H1963	lung	COSMIC	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation altering degron motif	0.6991
p.S511Y	SIDM01739	Small Cell Lung Carcinoma	GDSC	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation blocking phosphorylation signal	0.5556
p.S511Y	ACH-000297	Lung Cancer	CCLE	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation blocking phosphorylation signal	0.5556

Kaplan plot for PGM5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PGM5

UniProt ID: Q15124

Entrez ID: 5239

Protein name: Phosphoglucomutase-like protein 5 (Aciculin) (Phosphoglucomutase-related protein) (PGM-RP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PGM5 in