DegronMD - Q15124(PGM5)

FUNCTION: Component of adherens-type cell-cell and cell-matrix junctions (PubMed:8175905). Has no phosphoglucomutase activity in vitro (PubMed:8175905). {ECO:0000269|PubMed:8175905}.

GO - Biological processes (BP): carbohydrate metabolic process [GO:0005975]; cell adhesion [GO:0007155]; glucose metabolic process [GO:0006006]; myofibril assembly [GO:0030239]; striated muscle tissue development [GO:0014706]

GO - Molecular function (MF): intramolecular transferase activity, phosphotransferases [GO:0016868]; magnesium ion binding [GO:0000287]; structural molecule activity [GO:0005198]

GO - Cellular component (CC): adherens junction [GO:0005912]; cell-substrate junction [GO:0030055]; costamere [GO:0043034]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; dystrophin-associated glycoprotein complex [GO:0016010]; focal adhesion [GO:0005925]; intercalated disc [GO:0014704]; sarcolemma [GO:0... View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S525N	DO222843	MELA	ICGC	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation blocking phosphorylation signal	0.75
p.R520I	SIDM00760	Small Cell Lung Carcinoma	GDSC	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation altering degron motif	0.6991
p.R520I	ACH-000729	Lung Cancer	CCLE	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation altering degron motif	0.6991
p.R520I	NCI-H1963	lung	COSMIC	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation altering degron motif	0.6991
p.S513R	SIDM00221	Melanoma	GDSC	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation blocking phosphorylation signal	0.6111
p.A523T	TCGA-VR-A8EQ	ESCA	TCGA	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation altering degron motif	0.6028
p.A523T	DO46591	OV	ICGC	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation altering degron motif	0.6028
p.S511Y	SIDM01739	Small Cell Lung Carcinoma	GDSC	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation blocking phosphorylation signal	0.5556
p.S511Y	ACH-000297	Lung Cancer	CCLE	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation blocking phosphorylation signal	0.5556
p.T518S	TCGA-58-A46M	LUSC	TCGA	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation rewiring degron network	0.3056
p.T518S	DO45485	LUSC	ICGC	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation rewiring degron network	0.3056
p.E527K	TCGA-B5-A3FC	UCEC	TCGA	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation rewiring degron network	0.25
p.E527K	DO41871	UCEC	ICGC	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation rewiring degron network	0.25
p.R516W	TCGA-BR-8680	STAD	TCGA	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation rewiring degron network	0.25
p.R516W	TCGA-EI-6917	READ	TCGA	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation rewiring degron network	0.25
p.R516W	DO36881	READ	ICGC	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation rewiring degron network	0.25
p.R516W	DO47769	STAD	ICGC	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation rewiring degron network	0.25
p.D529Y	DO228952	LICA	ICGC	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation rewiring degron network	0.1944
p.G514C	DO229019	LICA	ICGC	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation rewiring degron network	0.1944
p.G514C	DO229034	LICA	ICGC	LRLYAE	LIG_APCC_ABBA_1	519:524	Mutation rewiring degron network	0.1944

Showing 1 to 20 of 30 entries

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No resistance data available for this Degron.

Kaplan plot for PGM5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PGM5

UniProt ID: Q15124

Entrez ID: 5239

Protein name: Phosphoglucomutase-like protein 5 (Aciculin) (Phosphoglucomutase-related protein) (PGM-RP)

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for PGM5 in