DegronMD

Uniprot ID: Q15124

Source protein: Phosphoglucomutase-like protein 5

Source gene: PGM5

Class: LIG_APCC_ABBA_1

Location: 519:524

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.937

ASA_SCORE: 38.0333

COIL: 0.1003

CONS_SCORE: 0.6693

DSS_SCORE: 0.3338

HELIX: 0.4788

FCONS_SCORE: 1.259

RIG_SCORE: 0.7914

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G532S	TCGA-06-0749	GBM	TCGA	LRLYAE	LIG_APCC_ABBA_1	0.1111
p.G532S	DO12694	GBM	ICGC	LRLYAE	LIG_APCC_ABBA_1	0.1111
p.G532S	SIDM01664	Prostate Carcinoma	GDSC	LRLYAE	LIG_APCC_ABBA_1	0.1111
p.T518S	TCGA-58-A46M	LUSC	TCGA	LRLYAE	LIG_APCC_ABBA_1	0.3056
p.T518S	DO45485	LUSC	ICGC	LRLYAE	LIG_APCC_ABBA_1	0.3056
p.E527K	TCGA-B5-A3FC	UCEC	TCGA	LRLYAE	LIG_APCC_ABBA_1	0.25
p.E527K	DO41871	UCEC	ICGC	LRLYAE	LIG_APCC_ABBA_1	0.25
p.H533L	TCGA-BA-A6DA	HNSC	TCGA	LRLYAE	LIG_APCC_ABBA_1	0.0833
p.H533L	DO44448	HNSC	ICGC	LRLYAE	LIG_APCC_ABBA_1	0.0833
p.R516W	TCGA-BR-8680	STAD	TCGA	LRLYAE	LIG_APCC_ABBA_1	0.25
p.R516W	TCGA-EI-6917	READ	TCGA	LRLYAE	LIG_APCC_ABBA_1	0.25
p.R516W	DO36881	READ	ICGC	LRLYAE	LIG_APCC_ABBA_1	0.25
p.R516W	DO47769	STAD	ICGC	LRLYAE	LIG_APCC_ABBA_1	0.25
p.P530S	TCGA-EE-A3AA	SKCM	TCGA	LRLYAE	LIG_APCC_ABBA_1	0.1667
p.P530S	DO222632	MELA	ICGC	LRLYAE	LIG_APCC_ABBA_1	0.1667
p.P530S	DO37571	SKCM	ICGC	LRLYAE	LIG_APCC_ABBA_1	0.1667
p.A523T	TCGA-VR-A8EQ	ESCA	TCGA	LRLYAE	LIG_APCC_ABBA_1	0.6028
p.A523T	DO46591	OV	ICGC	LRLYAE	LIG_APCC_ABBA_1	0.6028
p.G532C	DO228948	LICA	ICGC	LRLYAE	LIG_APCC_ABBA_1	0.1111
p.G532C	DO229031	LICA	ICGC	LRLYAE	LIG_APCC_ABBA_1	0.1111
p.D529Y	DO228952	LICA	ICGC	LRLYAE	LIG_APCC_ABBA_1	0.1944
p.G514C	DO229019	LICA	ICGC	LRLYAE	LIG_APCC_ABBA_1	0.1944
p.G514C	DO229034	LICA	ICGC	LRLYAE	LIG_APCC_ABBA_1	0.1944
p.S525N	DO222843	MELA	ICGC	LRLYAE	LIG_APCC_ABBA_1	0.75
p.S513R	SIDM00221	Melanoma	GDSC	LRLYAE	LIG_APCC_ABBA_1	0.6111
p.R520I	SIDM00760	Small Cell Lung Carcinoma	GDSC	LRLYAE	LIG_APCC_ABBA_1	0.6991
p.R520I	ACH-000729	Lung Cancer	CCLE	LRLYAE	LIG_APCC_ABBA_1	0.6991
p.R520I	NCI-H1963	lung	COSMIC	LRLYAE	LIG_APCC_ABBA_1	0.6991
p.S511Y	SIDM01739	Small Cell Lung Carcinoma	GDSC	LRLYAE	LIG_APCC_ABBA_1	0.5556
p.S511Y	ACH-000297	Lung Cancer	CCLE	LRLYAE	LIG_APCC_ABBA_1	0.5556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRLYAE

Degron related mutations and impact score

Drug responses associated with PGM5 mutations

All proteins holding degron of LRLYAE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15124	Phosphoglucomutase-like protein 5	LIG_APCC_ABBA_1	519:524	LRLYAE	APC,CDC20,FZR1	0.937	More...