DegronMD - Q15185(PTGES3)

PTGES3

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R68T	TCGA-D8-A27N	BRCA	TCGA	DRSILCCLR	DEG_APCC_DBOX_1	70:78	Mutation rewiring degron network	0.2778
p.R68T	DO3892	BRCA	ICGC	DRSILCCLR	DEG_APCC_DBOX_1	70:78	Mutation rewiring degron network	0.2778
p.L74V	TCGA-EO-A3B0	UCEC	TCGA	DRSILCCLR	DEG_APCC_DBOX_1	70:78	Mutation altering degron motif	0.6765
p.I73V	TCGA-FD-A43N	BLCA	TCGA	DRSILCCLR	DEG_APCC_DBOX_1	70:78	Mutation altering degron motif	0.5965
p.S64C	DO225046	BRCA	ICGC	DRSILCCLR	DEG_APCC_DBOX_1	70:78	Mutation blocking phosphorylation signal	0.6111
p.K65T	DO225346	BRCA	ICGC	DRSILCCLR	DEG_APCC_DBOX_1	70:78	Mutation blocking ubiquitination signal	0.6389
p.S82C	DO10044	COAD	ICGC	DRSILCCLR	DEG_APCC_DBOX_1	70:78	Mutation blocking phosphorylation signal	0.6667
p.R86H	DO232224	PBCA	ICGC	DRSILCCLR	DEG_APCC_DBOX_1	70:78	Mutation rewiring degron network	0.1111
p.R86C	DO229462	SKCA	ICGC	DRSILCCLR	DEG_APCC_DBOX_1	70:78	Mutation rewiring degron network	0.1111
p.R86C	DO48665	SKCM	ICGC	DRSILCCLR	DEG_APCC_DBOX_1	70:78	Mutation rewiring degron network	0.1111
p.R86C	DO41331	UCEC	ICGC	DRSILCCLR	DEG_APCC_DBOX_1	70:78	Mutation rewiring degron network	0.1111
p.M81T	DO47721	STAD	ICGC	DRSILCCLR	DEG_APCC_DBOX_1	70:78	Mutation rewiring degron network	0.25
p.N64D	LNZTA3WT4	central nervous system	COSMIC	DRSILCCLR	DEG_APCC_DBOX_1	70:78	Mutation blocking phosphorylation signal	0.6111
p.N61D	LNZTA3WT4	central nervous system	COSMIC	DRSILCCLR	DEG_APCC_DBOX_1	70:78	Mutation rewiring degron network	0.0833

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*NOTE: the Kaplan plots were collected from OncoLnc