DegronMD

Uniprot ID: Q15185

Source protein: Prostaglandin E synthase 3

Source gene: PTGES3

Class: DEG_APCC_DBOX_1

Location: 70:78

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5241

ASA_SCORE: 34.2556

COIL: 0.2266

CONS_SCORE: 0.7682

DSS_SCORE: 0.3024

HELIX: 0.0328

FCONS_SCORE: 1.0008

RIG_SCORE: 0.8439

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R68T	TCGA-D8-A27N	BRCA	TCGA	DRSILCCLR	DEG_APCC_DBOX_1	0.2778
p.R68T	DO3892	BRCA	ICGC	DRSILCCLR	DEG_APCC_DBOX_1	0.2778
p.L74V	TCGA-EO-A3B0	UCEC	TCGA	DRSILCCLR	DEG_APCC_DBOX_1	0.6765
p.I73V	TCGA-FD-A43N	BLCA	TCGA	DRSILCCLR	DEG_APCC_DBOX_1	0.5965
p.S64C	DO225046	BRCA	ICGC	DRSILCCLR	DEG_APCC_DBOX_1	0.6111
p.K65T	DO225346	BRCA	ICGC	DRSILCCLR	DEG_APCC_DBOX_1	0.6389
p.S82C	DO10044	COAD	ICGC	DRSILCCLR	DEG_APCC_DBOX_1	0.6667
p.R86H	DO232224	PBCA	ICGC	DRSILCCLR	DEG_APCC_DBOX_1	0.1111
p.R86C	DO229462	SKCA	ICGC	DRSILCCLR	DEG_APCC_DBOX_1	0.1111
p.R86C	DO48665	SKCM	ICGC	DRSILCCLR	DEG_APCC_DBOX_1	0.1111
p.R86C	DO41331	UCEC	ICGC	DRSILCCLR	DEG_APCC_DBOX_1	0.1111
p.M81T	DO47721	STAD	ICGC	DRSILCCLR	DEG_APCC_DBOX_1	0.25
p.N64D	LNZTA3WT4	central_nervous_system	COSMIC	DRSILCCLR	DEG_APCC_DBOX_1	0.6111
p.N61D	LNZTA3WT4	central_nervous_system	COSMIC	DRSILCCLR	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15185	Prostaglandin E synthase 3	DEG_APCC_DBOX_1	70:78	DRSILCCLR	APC,CDC20,FZR1	0.5241	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons