DegronMD - Q15262(PTPRK)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V933L	TCGA-55-8620	LUAD	TCGA	SRVILQPVE	DEG_APCC_DBOX_1	925:933	Mutation altering degron motif	0.6765
p.N915T	TCGA-AA-3845	COAD	TCGA	SRVILQPVE	DEG_APCC_DBOX_1	925:933	Mutation rewiring degron network	0.0556
p.N915T	TCGA-CM-6674	COAD	TCGA	SRVILQPVE	DEG_APCC_DBOX_1	925:933	Mutation rewiring degron network	0.0556
p.N915T	ACH-000919	Gastric Cancer	CCLE	SRVILQPVE	DEG_APCC_DBOX_1	925:933	Mutation rewiring degron network	0.0556
p.N915T	IM-95	stomach	COSMIC	SRVILQPVE	DEG_APCC_DBOX_1	925:933	Mutation rewiring degron network	0.0556
p.R916Q	TCGA-AX-A3G8	UCEC	TCGA	SRVILQPVE	DEG_APCC_DBOX_1	925:933	Mutation blocking phosphorylation signal	0.5278
p.N915K	TCGA-BR-4292	STAD	TCGA	SRVILQPVE	DEG_APCC_DBOX_1	925:933	Mutation rewiring degron network	0.0556
p.G918V	TCGA-BT-A3PH	BLCA	TCGA	SRVILQPVE	DEG_APCC_DBOX_1	925:933	Mutation rewiring degron network	0.1389
p.P937S	TCGA-CG-5728	STAD	TCGA	SRVILQPVE	DEG_APCC_DBOX_1	925:933	Mutation rewiring degron network	0.2222
p.D924N	TCGA-DX-AB2E	SARC	TCGA	SRVILQPVE	DEG_APCC_DBOX_1	925:933	Mutation rewiring degron network	0.3056
p.D930H	DO44377	CESC	ICGC	SRVILQPVE	DEG_APCC_DBOX_1	925:933	Mutation altering degron motif	0.7688
p.N941T	DO10020	COAD	ICGC	SRVILQPVE	DEG_APCC_DBOX_1	925:933	Mutation rewiring degron network	0.1111
p.N941T	DO10092	COAD	ICGC	SRVILQPVE	DEG_APCC_DBOX_1	925:933	Mutation rewiring degron network	0.1111
p.N941T	IM-95	stomach	COSMIC	SRVILQPVE	DEG_APCC_DBOX_1	925:933	Mutation rewiring degron network	0.1111
p.E919K	DO31949	OV	ICGC	SRVILQPVE	DEG_APCC_DBOX_1	925:933	Mutation rewiring degron network	0.1667
p.R942L	DO32829	PACA	ICGC	SRVILQPVE	DEG_APCC_DBOX_1	925:933	Mutation rewiring degron network	0.0833
p.E917K	DO50287	SKCM	ICGC	SRVILQPVE	DEG_APCC_DBOX_1	925:933	Mutation rewiring degron network	0.1111
p.N941K	DO38495	STAD	ICGC	SRVILQPVE	DEG_APCC_DBOX_1	925:933	Mutation rewiring degron network	0.1111
p.V931I	DO229248	THCA	ICGC	SRVILQPVE	DEG_APCC_DBOX_1	925:933	Mutation altering degron motif	0.7076
p.R942Q	DO41014	UCEC	ICGC	SRVILQPVE	DEG_APCC_DBOX_1	925:933	Mutation rewiring degron network	0.0833
p.A917S	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	SRVILQPVE	DEG_APCC_DBOX_1	925:933	Mutation rewiring degron network	0.1111
p.A917S	NCI-H2172	lung	COSMIC	SRVILQPVE	DEG_APCC_DBOX_1	925:933	Mutation rewiring degron network	0.1111
p.N931T	SIDM00602	Gastric Carcinoma	GDSC	SRVILQPVE	DEG_APCC_DBOX_1	925:933	Mutation altering degron motif	0.7055
p.N931T	IM-95	stomach	COSMIC	SRVILQPVE	DEG_APCC_DBOX_1	925:933	Mutation altering degron motif	0.7055
p.L930M	ACH-000806	Lymphoma	CCLE	SRVILQPVE	DEG_APCC_DBOX_1	925:933	Mutation altering degron motif	0.711
p.L930M	L-540	haematopoietic and lymphoid tissue	COSMIC	SRVILQPVE	DEG_APCC_DBOX_1	925:933	Mutation altering degron motif	0.711
p.Y918C	CAL-51	breast	COSMIC	SRVILQPVE	DEG_APCC_DBOX_1	925:933	Mutation rewiring degron network	0.1389
p.N927T	IM-95	stomach	COSMIC	SRVILQPVE	DEG_APCC_DBOX_1	925:933	Mutation altering degron motif	0.7055
p.L929M	L-540	haematopoietic and lymphoid tissue	COSMIC	SRVILQPVE	DEG_APCC_DBOX_1	925:933	Mutation altering degron motif	0.711
p.A927S	NCI-H2172	lung	COSMIC	SRVILQPVE	DEG_APCC_DBOX_1	925:933	Mutation altering degron motif	0.7588
p.L942M	L-540	haematopoietic and lymphoid tissue	COSMIC	SRVILQPVE	DEG_APCC_DBOX_1	925:933	Mutation rewiring degron network	0.0833

Kaplan plot for PTPRK in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PTPRK

UniProt ID: Q15262

Entrez ID: 5796

Protein name: Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PTPRK in