DegronMD

Uniprot ID: Q15262

Source protein: Receptor-type tyrosine-protein phosphatase kappa

Source gene: PTPRK

Class: DEG_APCC_DBOX_1

Location: 925:933

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8384

ASA_SCORE: 50.7

COIL: 0.5568

CONS_SCORE: 0.4738

DSS_SCORE: 0.3924

HELIX: 0.0108

FCONS_SCORE: 0.9838

RIG_SCORE: 0.7899

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V933L	TCGA-55-8620	LUAD	TCGA	SRVILQPVE	DEG_APCC_DBOX_1	0.6765
p.N915T	TCGA-AA-3845	COAD	TCGA	SRVILQPVE	DEG_APCC_DBOX_1	0.0556
p.N915T	TCGA-CM-6674	COAD	TCGA	SRVILQPVE	DEG_APCC_DBOX_1	0.0556
p.N915T	ACH-000919	Gastric Cancer	CCLE	SRVILQPVE	DEG_APCC_DBOX_1	0.0556
p.N915T	IM-95	stomach	COSMIC	SRVILQPVE	DEG_APCC_DBOX_1	0.0556
p.R916Q	TCGA-AX-A3G8	UCEC	TCGA	SRVILQPVE	DEG_APCC_DBOX_1	0.5278
p.N915K	TCGA-BR-4292	STAD	TCGA	SRVILQPVE	DEG_APCC_DBOX_1	0.0556
p.G918V	TCGA-BT-A3PH	BLCA	TCGA	SRVILQPVE	DEG_APCC_DBOX_1	0.1389
p.P937S	TCGA-CG-5728	STAD	TCGA	SRVILQPVE	DEG_APCC_DBOX_1	0.2222
p.D924N	TCGA-DX-AB2E	SARC	TCGA	SRVILQPVE	DEG_APCC_DBOX_1	0.3056
p.D930H	DO44377	CESC	ICGC	SRVILQPVE	DEG_APCC_DBOX_1	0.7688
p.N941T	DO10020	COAD	ICGC	SRVILQPVE	DEG_APCC_DBOX_1	0.1111
p.N941T	DO10092	COAD	ICGC	SRVILQPVE	DEG_APCC_DBOX_1	0.1111
p.N941T	IM-95	stomach	COSMIC	SRVILQPVE	DEG_APCC_DBOX_1	0.1111
p.E919K	DO31949	OV	ICGC	SRVILQPVE	DEG_APCC_DBOX_1	0.1667
p.R942L	DO32829	PACA	ICGC	SRVILQPVE	DEG_APCC_DBOX_1	0.0833
p.E917K	DO50287	SKCM	ICGC	SRVILQPVE	DEG_APCC_DBOX_1	0.1111
p.N941K	DO38495	STAD	ICGC	SRVILQPVE	DEG_APCC_DBOX_1	0.1111
p.V931I	DO229248	THCA	ICGC	SRVILQPVE	DEG_APCC_DBOX_1	0.7076
p.R942Q	DO41014	UCEC	ICGC	SRVILQPVE	DEG_APCC_DBOX_1	0.0833
p.A917S	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	SRVILQPVE	DEG_APCC_DBOX_1	0.1111
p.A917S	NCI-H2172	lung	COSMIC	SRVILQPVE	DEG_APCC_DBOX_1	0.1111
p.N931T	SIDM00602	Gastric Carcinoma	GDSC	SRVILQPVE	DEG_APCC_DBOX_1	0.7055
p.N931T	IM-95	stomach	COSMIC	SRVILQPVE	DEG_APCC_DBOX_1	0.7055
p.L930M	ACH-000806	Lymphoma	CCLE	SRVILQPVE	DEG_APCC_DBOX_1	0.711
p.L930M	L-540	haematopoietic_and_lymphoid_tissue	COSMIC	SRVILQPVE	DEG_APCC_DBOX_1	0.711
p.Y918C	CAL-51	breast	COSMIC	SRVILQPVE	DEG_APCC_DBOX_1	0.1389
p.N927T	IM-95	stomach	COSMIC	SRVILQPVE	DEG_APCC_DBOX_1	0.7055
p.L929M	L-540	haematopoietic_and_lymphoid_tissue	COSMIC	SRVILQPVE	DEG_APCC_DBOX_1	0.711
p.A927S	NCI-H2172	lung	COSMIC	SRVILQPVE	DEG_APCC_DBOX_1	0.7588
p.L942M	L-540	haematopoietic_and_lymphoid_tissue	COSMIC	SRVILQPVE	DEG_APCC_DBOX_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRVILQPVE

Degron related mutations and impact score

Drug responses associated with PTPRK mutations

All proteins holding degron of SRVILQPVE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15262	Receptor-type tyrosine-protein phosphatase kappa	DEG_APCC_DBOX_1	925:933	SRVILQPVE	APC,CDC20,FZR1	0.8384	More...