DegronMD - Q15329(E2F5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V260A	TCGA-B5-A11H	UCEC	TCGA	PVTPQKS	DEG_SCF_FBW7_1	259:265	Mutation altering degron motif	0.5825
p.P259A	TCGA-CV-6948	HNSC	TCGA	PVTPQKS	DEG_SCF_FBW7_1	259:265	Mutation altering degron motif	0.7503
p.P262L	TCGA-D3-A3ML	SKCM	TCGA	PVTPQKS	DEG_SCF_FBW7_1	259:265	Mutation altering degron motif	0.7582
p.P262L	DO47413	SKCM	ICGC	PVTPQKS	DEG_SCF_FBW7_1	259:265	Mutation altering degron motif	0.7582
p.P262L	SIDM01608	Endometrial Carcinoma	GDSC	PVTPQKS	DEG_SCF_FBW7_1	259:265	Mutation altering degron motif	0.7582
p.P262L	ACH-000990	Endometrial/Uterine Cancer	CCLE	PVTPQKS	DEG_SCF_FBW7_1	259:265	Mutation altering degron motif	0.7582
p.S253F	TCGA-ER-A42L	SKCM	TCGA	PVTPQKS	DEG_SCF_FBW7_1	259:265	Mutation rewiring degron network	0.1667
p.T250A	TCGA-IB-7651	PAAD	TCGA	PVTPQKS	DEG_SCF_FBW7_1	259:265	Mutation rewiring degron network	0.0833
p.P260A	DO14188	HNSC	ICGC	PVTPQKS	DEG_SCF_FBW7_1	259:265	Mutation altering degron motif	0.7503
p.S254P	DO228355	MALY	ICGC	PVTPQKS	DEG_SCF_FBW7_1	259:265	Mutation blocking phosphorylation signal	0.6389
p.T251A	DO46657	PAAD	ICGC	PVTPQKS	DEG_SCF_FBW7_1	259:265	Mutation rewiring degron network	0.1111
p.Q251P	DO35442	PACA	ICGC	PVTPQKS	DEG_SCF_FBW7_1	259:265	Mutation rewiring degron network	0.1111
p.S254F	DO223910	SKCM	ICGC	PVTPQKS	DEG_SCF_FBW7_1	259:265	Mutation blocking phosphorylation signal	0.6389
p.V261A	DO42825	UCEC	ICGC	PVTPQKS	DEG_SCF_FBW7_1	259:265	Mutation altering degron motif	0.6936
p.A268T	SIDM01278	Colorectal Carcinoma	GDSC	PVTPQKS	DEG_SCF_FBW7_1	259:265	Mutation rewiring degron network	0.25
p.L257S	SIDM00845	Burkitt's Lymphoma	GDSC	PVTPQKS	DEG_SCF_FBW7_1	259:265	Mutation rewiring degron network	0.2778
p.P259S	SIDM00845	Burkitt's Lymphoma	GDSC	PVTPQKS	DEG_SCF_FBW7_1	259:265	Mutation altering degron motif	0.6752

Kaplan plot for E2F5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

E2F5

UniProt ID: Q15329

Entrez ID: 1875

Protein name: Transcription factor E2F5 (E2F-5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for E2F5 in