DegronMD

Uniprot ID: Q15329

Source protein: Transcription factor E2F5

Source gene: E2F5

Class: DEG_SCF_FBW7_1

Location: 259:265

E3 ligase: FBXW7

DEGRON score: 0.9934

ASA_SCORE: 97.1571

COIL: 0.935

CONS_SCORE: 0.3998

DSS_SCORE: 0.7154

HELIX: 0.0443

FCONS_SCORE: 0.9778

RIG_SCORE: 0.6426

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V260A	TCGA-B5-A11H	UCEC	TCGA	PVTPQKS	DEG_SCF_FBW7_1	0.5825
p.P259A	TCGA-CV-6948	HNSC	TCGA	PVTPQKS	DEG_SCF_FBW7_1	0.7503
p.P262L	TCGA-D3-A3ML	SKCM	TCGA	PVTPQKS	DEG_SCF_FBW7_1	0.7582
p.P262L	DO47413	SKCM	ICGC	PVTPQKS	DEG_SCF_FBW7_1	0.7582
p.P262L	SIDM01608	Endometrial Carcinoma	GDSC	PVTPQKS	DEG_SCF_FBW7_1	0.7582
p.P262L	ACH-000990	Endometrial/Uterine Cancer	CCLE	PVTPQKS	DEG_SCF_FBW7_1	0.7582
p.S253F	TCGA-ER-A42L	SKCM	TCGA	PVTPQKS	DEG_SCF_FBW7_1	0.1667
p.T250A	TCGA-IB-7651	PAAD	TCGA	PVTPQKS	DEG_SCF_FBW7_1	0.0833
p.P260A	DO14188	HNSC	ICGC	PVTPQKS	DEG_SCF_FBW7_1	0.7503
p.S254P	DO228355	MALY	ICGC	PVTPQKS	DEG_SCF_FBW7_1	0.6389
p.T251A	DO46657	PAAD	ICGC	PVTPQKS	DEG_SCF_FBW7_1	0.1111
p.Q251P	DO35442	PACA	ICGC	PVTPQKS	DEG_SCF_FBW7_1	0.1111
p.S254F	DO223910	SKCM	ICGC	PVTPQKS	DEG_SCF_FBW7_1	0.6389
p.V261A	DO42825	UCEC	ICGC	PVTPQKS	DEG_SCF_FBW7_1	0.6936
p.A268T	SIDM01278	Colorectal Carcinoma	GDSC	PVTPQKS	DEG_SCF_FBW7_1	0.25
p.L257S	SIDM00845	Burkitt's Lymphoma	GDSC	PVTPQKS	DEG_SCF_FBW7_1	0.2778
p.P259S	SIDM00845	Burkitt's Lymphoma	GDSC	PVTPQKS	DEG_SCF_FBW7_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15329	Transcription factor E2F5	DEG_SCF_FBW7_1	259:265	PVTPQKS	FBXW7	0.9934	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons