DegronMD - Q15334(LLGL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V517M	TCGA-AP-A1DR	UCEC	TCGA	FDPYSD	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.1667
p.V517M	DO43747	UCEC	ICGC	FDPYSD	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.1667
p.D512N	TCGA-CG-4305	STAD	TCGA	FDPYSD	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.3056
p.D512N	DO38823	STAD	ICGC	FDPYSD	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.3056
p.P513L	TCGA-DA-A95Z	SKCM	TCGA	FDPYSD	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.2778
p.P513L	DO219481	SKCM	ICGC	FDPYSD	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.2778
p.R514Q	TCGA-EO-A22U	UCEC	TCGA	FDPYSD	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.25
p.R514Q	DO43755	UCEC	ICGC	FDPYSD	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.25
p.G504C	TCGA-GN-A26C	SKCM	TCGA	FDPYSD	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.2778
p.G504C	DO37782	SKCM	ICGC	FDPYSD	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.2778
p.R501H	DO229389	BTCA	ICGC	FDPYSD	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.1944
p.R501C	DO48266	ESCA	ICGC	FDPYSD	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.1944
p.D507N	DO222567	MELA	ICGC	FDPYSD	LIG_APCC_ABBA_1	506:511	Mutation altering degron motif	0.5821
p.C505S	DO42256	UCEC	ICGC	FDPYSD	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.3056
p.A521V	SIDM00966	Ovarian Carcinoma	GDSC	FDPYSD	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.0556
p.A521G	SIDM01190	Bladder Carcinoma	GDSC	FDPYSD	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.0556
p.A521G	ACH-000720	Bladder Cancer	CCLE	FDPYSD	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.0556
p.A521G	TCCSUP	urinary tract	COSMIC	FDPYSD	LIG_APCC_ABBA_1	506:511	Mutation rewiring degron network	0.0556

Kaplan plot for LLGL1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LLGL1

UniProt ID: Q15334

Entrez ID: 3996

Protein name: Lethal(2) giant larvae protein homolog 1 (LLGL) (DLG4) (Hugl-1) (Human homolog to the D-lgl gene protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LLGL1 in