DegronMD

Uniprot ID: Q15334

Source protein: Lethal

Source gene: LLGL1

Class: LIG_APCC_ABBA_1

Location: 506:511

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7747

ASA_SCORE: 57.6167

COIL: 0.809

CONS_SCORE: 0.8189

DSS_SCORE: 0.2331

HELIX: 0.0563

FCONS_SCORE: 1.1322

RIG_SCORE: 0.7832

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V517M	TCGA-AP-A1DR	UCEC	TCGA	FDPYSD	LIG_APCC_ABBA_1	0.1667
p.V517M	DO43747	UCEC	ICGC	FDPYSD	LIG_APCC_ABBA_1	0.1667
p.D512N	TCGA-CG-4305	STAD	TCGA	FDPYSD	LIG_APCC_ABBA_1	0.3056
p.D512N	DO38823	STAD	ICGC	FDPYSD	LIG_APCC_ABBA_1	0.3056
p.P513L	TCGA-DA-A95Z	SKCM	TCGA	FDPYSD	LIG_APCC_ABBA_1	0.2778
p.P513L	DO219481	SKCM	ICGC	FDPYSD	LIG_APCC_ABBA_1	0.2778
p.R514Q	TCGA-EO-A22U	UCEC	TCGA	FDPYSD	LIG_APCC_ABBA_1	0.25
p.R514Q	DO43755	UCEC	ICGC	FDPYSD	LIG_APCC_ABBA_1	0.25
p.G504C	TCGA-GN-A26C	SKCM	TCGA	FDPYSD	LIG_APCC_ABBA_1	0.2778
p.G504C	DO37782	SKCM	ICGC	FDPYSD	LIG_APCC_ABBA_1	0.2778
p.R501H	DO229389	BTCA	ICGC	FDPYSD	LIG_APCC_ABBA_1	0.1944
p.R501C	DO48266	ESCA	ICGC	FDPYSD	LIG_APCC_ABBA_1	0.1944
p.D507N	DO222567	MELA	ICGC	FDPYSD	LIG_APCC_ABBA_1	0.5821
p.C505S	DO42256	UCEC	ICGC	FDPYSD	LIG_APCC_ABBA_1	0.3056
p.A521V	SIDM00966	Ovarian Carcinoma	GDSC	FDPYSD	LIG_APCC_ABBA_1	0.0556
p.A521G	SIDM01190	Bladder Carcinoma	GDSC	FDPYSD	LIG_APCC_ABBA_1	0.0556
p.A521G	ACH-000720	Bladder Cancer	CCLE	FDPYSD	LIG_APCC_ABBA_1	0.0556
p.A521G	TCCSUP	urinary_tract	COSMIC	FDPYSD	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15334	Lethal	LIG_APCC_ABBA_1	506:511	FDPYSD	APC,CDC20,FZR1	0.7747	More...
Q6P1M3	LLGL scribble cell polarity complex component 2	LIG_APCC_ABBA_1	496:501	FDPYSD	APC,CDC20,FZR1	0.8962	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons