DegronMD

Uniprot ID: Q6P1M3

Source protein: LLGL scribble cell polarity complex component 2

Source gene: LLGL2

Class: LIG_APCC_ABBA_1

Location: 496:501

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8962

ASA_SCORE: 54.6667

COIL: 0.8657

CONS_SCORE: 0.5712

DSS_SCORE: 0.3372

HELIX: 0.054

FCONS_SCORE: 1.1219

RIG_SCORE: 0.7574

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D497N	TCGA-B5-A3FA	UCEC	TCGA	FDPYSD	LIG_APCC_ABBA_1	0.5821
p.D497N	DO52402	UCEC	ICGC	FDPYSD	LIG_APCC_ABBA_1	0.5821
p.S495F	TCGA-CV-7568	HNSC	TCGA	FDPYSD	LIG_APCC_ABBA_1	0.3056
p.S495F	DO14160	HNSC	ICGC	FDPYSD	LIG_APCC_ABBA_1	0.3056
p.P503L	TCGA-EE-A2GO	SKCM	TCGA	FDPYSD	LIG_APCC_ABBA_1	0.2778
p.P503L	TCGA-FR-A726	SKCM	TCGA	FDPYSD	LIG_APCC_ABBA_1	0.2778
p.P503L	DO37823	SKCM	ICGC	FDPYSD	LIG_APCC_ABBA_1	0.2778
p.P503L	DO48665	SKCM	ICGC	FDPYSD	LIG_APCC_ABBA_1	0.2778
p.D502N	TCGA-ZF-A9RD	BLCA	TCGA	FDPYSD	LIG_APCC_ABBA_1	0.3056
p.D502N	DO219070	BLCA	ICGC	FDPYSD	LIG_APCC_ABBA_1	0.3056
p.D502N	DO37138	READ	ICGC	FDPYSD	LIG_APCC_ABBA_1	0.3056
p.R504L	DO229034	LICA	ICGC	FDPYSD	LIG_APCC_ABBA_1	0.25
p.I510V	DO231808	LINC	ICGC	FDPYSD	LIG_APCC_ABBA_1	0.0833
p.G494C	SIDM00663	Melanoma	GDSC	FDPYSD	LIG_APCC_ABBA_1	0.2778
p.G494C	ACH-000814	Skin Cancer	CCLE	FDPYSD	LIG_APCC_ABBA_1	0.2778
p.G506D	SIDM00364	B-Lymphoblastic Leukemia	GDSC	FDPYSD	LIG_APCC_ABBA_1	0.1944
p.G506D	ACH-002059	Leukemia	CCLE	FDPYSD	LIG_APCC_ABBA_1	0.1944
p.G506D	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	FDPYSD	LIG_APCC_ABBA_1	0.1944
p.R491C	SIDM01012	Other Blood Cancers	GDSC	FDPYSD	LIG_APCC_ABBA_1	0.1944
p.R491C	JVM-3	haematopoietic_and_lymphoid_tissue	COSMIC	FDPYSD	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15334	Lethal	LIG_APCC_ABBA_1	506:511	FDPYSD	APC,CDC20,FZR1	0.7747	More...
Q6P1M3	LLGL scribble cell polarity complex component 2	LIG_APCC_ABBA_1	496:501	FDPYSD	APC,CDC20,FZR1	0.8962	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons