DegronMD - Q6P1M3(LLGL2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L693M	TCGA-AX-A06F	UCEC	TCGA	ERPGLQNME	DEG_APCC_DBOX_1	684:692	Mutation rewiring degron network	0.3056
p.L693M	DO41752	UCEC	ICGC	ERPGLQNME	DEG_APCC_DBOX_1	684:692	Mutation rewiring degron network	0.3056
p.D497N	TCGA-B5-A3FA	UCEC	TCGA	FDPYSD	LIG_APCC_ABBA_1	496:501	Mutation altering degron motif	0.5821
p.D497N	DO52402	UCEC	ICGC	FDPYSD	LIG_APCC_ABBA_1	496:501	Mutation altering degron motif	0.5821
p.S495F	TCGA-CV-7568	HNSC	TCGA	FDPYSD	LIG_APCC_ABBA_1	496:501	Mutation rewiring degron network	0.3056
p.S495F	DO14160	HNSC	ICGC	FDPYSD	LIG_APCC_ABBA_1	496:501	Mutation rewiring degron network	0.3056
p.P503L	TCGA-EE-A2GO	SKCM	TCGA	FDPYSD	LIG_APCC_ABBA_1	496:501	Mutation rewiring degron network	0.2778
p.P503L	TCGA-FR-A726	SKCM	TCGA	FDPYSD	LIG_APCC_ABBA_1	496:501	Mutation rewiring degron network	0.2778
p.P503L	DO37823	SKCM	ICGC	FDPYSD	LIG_APCC_ABBA_1	496:501	Mutation rewiring degron network	0.2778
p.P503L	DO48665	SKCM	ICGC	FDPYSD	LIG_APCC_ABBA_1	496:501	Mutation rewiring degron network	0.2778
p.D502N	TCGA-ZF-A9RD	BLCA	TCGA	FDPYSD	LIG_APCC_ABBA_1	496:501	Mutation rewiring degron network	0.3056
p.D502N	DO219070	BLCA	ICGC	FDPYSD	LIG_APCC_ABBA_1	496:501	Mutation rewiring degron network	0.3056
p.D502N	DO37138	READ	ICGC	FDPYSD	LIG_APCC_ABBA_1	496:501	Mutation rewiring degron network	0.3056
p.R504L	DO229034	LICA	ICGC	FDPYSD	LIG_APCC_ABBA_1	496:501	Mutation rewiring degron network	0.25
p.G687S	DO50970	LICA	ICGC	ERPGLQNME	DEG_APCC_DBOX_1	684:692	Mutation altering degron motif	0.5882
p.I510V	DO231808	LINC	ICGC	FDPYSD	LIG_APCC_ABBA_1	496:501	Mutation rewiring degron network	0.0833
p.E678K	DO219878	SKCA	ICGC	ERPGLQNME	DEG_APCC_DBOX_1	684:692	Mutation rewiring degron network	0.1667
p.G494C	SIDM00663	Melanoma	GDSC	FDPYSD	LIG_APCC_ABBA_1	496:501	Mutation rewiring degron network	0.2778
p.G494C	ACH-000814	Skin Cancer	CCLE	FDPYSD	LIG_APCC_ABBA_1	496:501	Mutation rewiring degron network	0.2778
p.S680T	SIDM01040	Ovarian Carcinoma	GDSC	ERPGLQNME	DEG_APCC_DBOX_1	684:692	Mutation blocking phosphorylation signal	0.6667
p.S680T	ACH-000574	Ovarian Cancer	CCLE	ERPGLQNME	DEG_APCC_DBOX_1	684:692	Mutation blocking phosphorylation signal	0.6667
p.S680T	FU-OV-1	ovary	COSMIC	ERPGLQNME	DEG_APCC_DBOX_1	684:692	Mutation blocking phosphorylation signal	0.6667
p.G506D	SIDM00364	B-Lymphoblastic Leukemia	GDSC	FDPYSD	LIG_APCC_ABBA_1	496:501	Mutation rewiring degron network	0.1944
p.G506D	ACH-002059	Leukemia	CCLE	FDPYSD	LIG_APCC_ABBA_1	496:501	Mutation rewiring degron network	0.1944
p.G506D	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	FDPYSD	LIG_APCC_ABBA_1	496:501	Mutation rewiring degron network	0.1944
p.K682E	SIDM00893	Breast Carcinoma	GDSC	ERPGLQNME	DEG_APCC_DBOX_1	684:692	Mutation blocking ubiquitination signal	0.7222
p.K682E	ACH-000536	Breast Cancer	CCLE	ERPGLQNME	DEG_APCC_DBOX_1	684:692	Mutation blocking ubiquitination signal	0.7222
p.K682E	BT-20	breast	COSMIC	ERPGLQNME	DEG_APCC_DBOX_1	684:692	Mutation blocking ubiquitination signal	0.7222
p.R698C	SIDM01088	Endometrial Carcinoma	GDSC	ERPGLQNME	DEG_APCC_DBOX_1	684:692	Mutation rewiring degron network	0.1667
p.R491C	SIDM01012	Other Blood Cancers	GDSC	FDPYSD	LIG_APCC_ABBA_1	496:501	Mutation rewiring degron network	0.1944
p.R491C	JVM-3	haematopoietic and lymphoid tissue	COSMIC	FDPYSD	LIG_APCC_ABBA_1	496:501	Mutation rewiring degron network	0.1944

Kaplan plot for LLGL2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LLGL2

UniProt ID: Q6P1M3

Entrez ID: 3993

Protein name: LLGL scribble cell polarity complex component 2 (HGL) (Lethal(2) giant larvae protein homolog 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LLGL2 in