DegronMD

Uniprot ID: Q6P1M3

Source protein: LLGL scribble cell polarity complex component 2

Source gene: LLGL2

Class: DEG_APCC_DBOX_1

Location: 684:692

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8423

ASA_SCORE: 96.6333

COIL: 0.7139

CONS_SCORE: 0.2968

DSS_SCORE: 0.6171

HELIX: 0.2388

FCONS_SCORE: 0.7357

RIG_SCORE: 0.6715

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L693M	TCGA-AX-A06F	UCEC	TCGA	ERPGLQNME	DEG_APCC_DBOX_1	0.3056
p.L693M	DO41752	UCEC	ICGC	ERPGLQNME	DEG_APCC_DBOX_1	0.3056
p.G687S	DO50970	LICA	ICGC	ERPGLQNME	DEG_APCC_DBOX_1	0.5882
p.E678K	DO219878	SKCA	ICGC	ERPGLQNME	DEG_APCC_DBOX_1	0.1667
p.S680T	SIDM01040	Ovarian Carcinoma	GDSC	ERPGLQNME	DEG_APCC_DBOX_1	0.6667
p.S680T	ACH-000574	Ovarian Cancer	CCLE	ERPGLQNME	DEG_APCC_DBOX_1	0.6667
p.S680T	FU-OV-1	ovary	COSMIC	ERPGLQNME	DEG_APCC_DBOX_1	0.6667
p.K682E	SIDM00893	Breast Carcinoma	GDSC	ERPGLQNME	DEG_APCC_DBOX_1	0.7222
p.K682E	ACH-000536	Breast Cancer	CCLE	ERPGLQNME	DEG_APCC_DBOX_1	0.7222
p.K682E	BT-20	breast	COSMIC	ERPGLQNME	DEG_APCC_DBOX_1	0.7222
p.R698C	SIDM01088	Endometrial Carcinoma	GDSC	ERPGLQNME	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P1M3	LLGL scribble cell polarity complex component 2	DEG_APCC_DBOX_1	684:692	ERPGLQNME	APC,CDC20,FZR1	0.8423	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons