DegronMD - Q15386(UBE3C)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R70I	TCGA-2W-A8YY	CESC	TCGA	IQSFIRGYRDR	SCF_FBXL2	52:62	Mutation rewiring degron network	0.1111
p.R70I	DO223732	CESC	ICGC	IQSFIRGYRDR	SCF_FBXL2	52:62	Mutation rewiring degron network	0.1111
p.R57Q	TCGA-AX-A05Z	UCEC	TCGA	IQSFIRGYRDR	SCF_FBXL2	52:62	Mutation altering degron motif	0.7329
p.R57Q	DO40884	UCEC	ICGC	IQSFIRGYRDR	SCF_FBXL2	52:62	Mutation altering degron motif	0.7329
p.R45S	TCGA-B0-4698	KIRC	TCGA	IQSFIRGYRDR	SCF_FBXL2	52:62	Mutation rewiring degron network	0.1389
p.R45S	DO20368	KIRC	ICGC	IQSFIRGYRDR	SCF_FBXL2	52:62	Mutation rewiring degron network	0.1389
p.R44Q	TCGA-DK-A6AW	BLCA	TCGA	IQSFIRGYRDR	SCF_FBXL2	52:62	Mutation rewiring degron network	0.1111
p.R44Q	TCGA-KQ-A41S	BLCA	TCGA	IQSFIRGYRDR	SCF_FBXL2	52:62	Mutation rewiring degron network	0.1111
p.R44Q	DO48566	BLCA	ICGC	IQSFIRGYRDR	SCF_FBXL2	52:62	Mutation rewiring degron network	0.1111
p.R44Q	DO223593	BLCA	ICGC	IQSFIRGYRDR	SCF_FBXL2	52:62	Mutation rewiring degron network	0.1111
p.E42Q	DO225215	BRCA	ICGC	IQSFIRGYRDR	SCF_FBXL2	52:62	Mutation rewiring degron network	0.0556
p.E42Q	DO227836	BRCA	ICGC	IQSFIRGYRDR	SCF_FBXL2	52:62	Mutation rewiring degron network	0.0556
p.R70T	DO222621	BTCA	ICGC	IQSFIRGYRDR	SCF_FBXL2	52:62	Mutation rewiring degron network	0.1111
p.S67F	DO50346	ESAD	ICGC	IQSFIRGYRDR	SCF_FBXL2	52:62	Mutation rewiring degron network	0.1944
p.L46F	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	IQSFIRGYRDR	SCF_FBXL2	52:62	Mutation rewiring degron network	0.1667
p.L46F	ACH-002215	Lymphoma	CCLE	IQSFIRGYRDR	SCF_FBXL2	52:62	Mutation rewiring degron network	0.1667
p.L46F	BC-3	haematopoietic and lymphoid tissue	COSMIC	IQSFIRGYRDR	SCF_FBXL2	52:62	Mutation rewiring degron network	0.1667
p.P44R	THP-1	haematopoietic and lymphoid tissue	COSMIC	IQSFIRGYRDR	SCF_FBXL2	52:62	Mutation rewiring degron network	0.1111

Kaplan plot for UBE3C in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UBE3C

UniProt ID: Q15386

Entrez ID: 9690

Protein name: Ubiquitin-protein ligase E3C (EC 2.3.2.26) (HECT-type ubiquitin transferase E3C) (Homologous to E6AP carboxyl terminus homologous protein 2) (HectH2) (RTA-associated ubiquitin ligase) (RAUL)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for UBE3C in