DegronMD

Uniprot ID: Q15386

Source protein: Ubiquitin-protein ligase E3C

Source gene: UBE3C

Class: SCF_FBXL2

Location: 52:62

E3 ligase: FBXL2

DEGRON score: 0.5807

ASA_SCORE: 58.0091

COIL: 0.0129

CONS_SCORE: 0.4702

DSS_SCORE: 0.294

HELIX: 0.9865

FCONS_SCORE: 1.1739

RIG_SCORE: 0.8397

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R70I	TCGA-2W-A8YY	CESC	TCGA	IQSFIRGYRDR	SCF_FBXL2	0.1111
p.R70I	DO223732	CESC	ICGC	IQSFIRGYRDR	SCF_FBXL2	0.1111
p.R57Q	TCGA-AX-A05Z	UCEC	TCGA	IQSFIRGYRDR	SCF_FBXL2	0.7329
p.R57Q	DO40884	UCEC	ICGC	IQSFIRGYRDR	SCF_FBXL2	0.7329
p.R45S	TCGA-B0-4698	KIRC	TCGA	IQSFIRGYRDR	SCF_FBXL2	0.1389
p.R45S	DO20368	KIRC	ICGC	IQSFIRGYRDR	SCF_FBXL2	0.1389
p.R44Q	TCGA-DK-A6AW	BLCA	TCGA	IQSFIRGYRDR	SCF_FBXL2	0.1111
p.R44Q	TCGA-KQ-A41S	BLCA	TCGA	IQSFIRGYRDR	SCF_FBXL2	0.1111
p.R44Q	DO48566	BLCA	ICGC	IQSFIRGYRDR	SCF_FBXL2	0.1111
p.R44Q	DO223593	BLCA	ICGC	IQSFIRGYRDR	SCF_FBXL2	0.1111
p.E42Q	DO225215	BRCA	ICGC	IQSFIRGYRDR	SCF_FBXL2	0.0556
p.E42Q	DO227836	BRCA	ICGC	IQSFIRGYRDR	SCF_FBXL2	0.0556
p.R70T	DO222621	BTCA	ICGC	IQSFIRGYRDR	SCF_FBXL2	0.1111
p.S67F	DO50346	ESAD	ICGC	IQSFIRGYRDR	SCF_FBXL2	0.1944
p.L46F	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	IQSFIRGYRDR	SCF_FBXL2	0.1667
p.L46F	ACH-002215	Lymphoma	CCLE	IQSFIRGYRDR	SCF_FBXL2	0.1667
p.L46F	BC-3	haematopoietic_and_lymphoid_tissue	COSMIC	IQSFIRGYRDR	SCF_FBXL2	0.1667
p.P44R	THP-1	haematopoietic_and_lymphoid_tissue	COSMIC	IQSFIRGYRDR	SCF_FBXL2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15386	Ubiquitin-protein ligase E3C	SCF_FBXL2	52:62	IQSFIRGYRDR	FBXL2	0.5807	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons