DegronMD - Q15560(TCEA2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S121L	TCGA-A5-A2K5	UCEC	TCGA	PSTPRIT	DEG_SCF_FBW7_1	120:126	Mutation altering degron motif	0.7667
p.S121L	DO41379	UCEC	ICGC	PSTPRIT	DEG_SCF_FBW7_1	120:126	Mutation altering degron motif	0.7667
p.P130T	TCGA-CV-7178	HNSC	TCGA	PSTPRIT	DEG_SCF_FBW7_1	120:126	Mutation rewiring degron network	0.2222
p.P130T	DO14774	HNSC	ICGC	PSTPRIT	DEG_SCF_FBW7_1	120:126	Mutation rewiring degron network	0.2222
p.P130Q	TCGA-D3-A3CB	SKCM	TCGA	PSTPRIT	DEG_SCF_FBW7_1	120:126	Mutation rewiring degron network	0.2222
p.P130Q	DO47386	SKCM	ICGC	PSTPRIT	DEG_SCF_FBW7_1	120:126	Mutation rewiring degron network	0.2222
p.P129L	TCGA-FS-A1YY	SKCM	TCGA	PSTPRIT	DEG_SCF_FBW7_1	120:126	Mutation rewiring degron network	0.25
p.P129L	DO37415	SKCM	ICGC	PSTPRIT	DEG_SCF_FBW7_1	120:126	Mutation rewiring degron network	0.25
p.P130S	TCGA-FS-A1YY	SKCM	TCGA	PSTPRIT	DEG_SCF_FBW7_1	120:126	Mutation rewiring degron network	0.2222
p.P130S	DO229177	LMS	ICGC	PSTPRIT	DEG_SCF_FBW7_1	120:126	Mutation rewiring degron network	0.2222
p.P130S	DO37415	SKCM	ICGC	PSTPRIT	DEG_SCF_FBW7_1	120:126	Mutation rewiring degron network	0.2222
p.F128L	TCGA-XF-A9T3	BLCA	TCGA	PSTPRIT	DEG_SCF_FBW7_1	120:126	Mutation rewiring degron network	0.2778
p.F128L	DO51922	BLCA	ICGC	PSTPRIT	DEG_SCF_FBW7_1	120:126	Mutation rewiring degron network	0.2778
p.A119V	DO228122	EOPC	ICGC	PSTPRIT	DEG_SCF_FBW7_1	120:126	Mutation rewiring degron network	0.3056
p.P114L	DO234338	ESAD	ICGC	PSTPRIT	DEG_SCF_FBW7_1	120:126	Mutation rewiring degron network	0.1667
p.P114L	DO234303	ESAD	ICGC	PSTPRIT	DEG_SCF_FBW7_1	120:126	Mutation rewiring degron network	0.1667
p.P120S	DO233082	GACA	ICGC	PSTPRIT	DEG_SCF_FBW7_1	120:126	Mutation altering degron motif	0.6752
p.R113S	DO228948	LICA	ICGC	PSTPRIT	DEG_SCF_FBW7_1	120:126	Mutation rewiring degron network	0.1389
p.R124M	DO228948	LICA	ICGC	PSTPRIT	DEG_SCF_FBW7_1	120:126	Mutation altering degron motif	0.7521
p.P117L	DO23136	LINC	ICGC	PSTPRIT	DEG_SCF_FBW7_1	120:126	Mutation rewiring degron network	0.25
p.P120L	DO229177	LMS	ICGC	PSTPRIT	DEG_SCF_FBW7_1	120:126	Mutation altering degron motif	0.6471
p.S110R	DO229257	THCA	ICGC	PSTPRIT	DEG_SCF_FBW7_1	120:126	Mutation blocking phosphorylation signal	0.5
p.P117S	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PSTPRIT	DEG_SCF_FBW7_1	120:126	Mutation rewiring degron network	0.25
p.P117S	ACH-002222	Leukemia	CCLE	PSTPRIT	DEG_SCF_FBW7_1	120:126	Mutation rewiring degron network	0.25
p.A119T	ACH-000999	Colon/Colorectal Cancer	CCLE	PSTPRIT	DEG_SCF_FBW7_1	120:126	Mutation rewiring degron network	0.3056
p.T125M	MOG-G-UVW	central nervous system	COSMIC	PSTPRIT	DEG_SCF_FBW7_1	120:126	Mutation altering degron motif	0.7423

Kaplan plot for TCEA2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TCEA2

UniProt ID: Q15560

Entrez ID: 6919

Protein name: Transcription elongation factor A protein 2 (Testis-specific S-II) (Transcription elongation factor S-II protein 2) (Transcription elongation factor TFIIS.l)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TCEA2 in