DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PSTPRIT
Uniprot ID:
Q15560
Source protein:
Transcription elongation factor A protein 2
Source gene:
TCEA2
Class:
DEG_SCF_FBW7_1
Location:
120:126
E3 ligase:
FBXW7
DEGRON score:
0.996
ASA_SCORE:
95.1857
COIL:
0.9333
CONS_SCORE:
0.37
DSS_SCORE:
0.6304
HELIX:
0.027
FCONS_SCORE:
1.0521
RIG_SCORE:
0.6169
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S121L
TCGA-A5-A2K5
UCEC
TCGA
PSTPRIT
DEG_SCF_FBW7_1
0.7667
p.S121L
DO41379
UCEC
ICGC
PSTPRIT
DEG_SCF_FBW7_1
0.7667
p.P130T
TCGA-CV-7178
HNSC
TCGA
PSTPRIT
DEG_SCF_FBW7_1
0.2222
p.P130T
DO14774
HNSC
ICGC
PSTPRIT
DEG_SCF_FBW7_1
0.2222
p.P130Q
TCGA-D3-A3CB
SKCM
TCGA
PSTPRIT
DEG_SCF_FBW7_1
0.2222
p.P130Q
DO47386
SKCM
ICGC
PSTPRIT
DEG_SCF_FBW7_1
0.2222
p.P129L
TCGA-FS-A1YY
SKCM
TCGA
PSTPRIT
DEG_SCF_FBW7_1
0.25
p.P129L
DO37415
SKCM
ICGC
PSTPRIT
DEG_SCF_FBW7_1
0.25
p.P130S
TCGA-FS-A1YY
SKCM
TCGA
PSTPRIT
DEG_SCF_FBW7_1
0.2222
p.P130S
DO229177
LMS
ICGC
PSTPRIT
DEG_SCF_FBW7_1
0.2222
p.P130S
DO37415
SKCM
ICGC
PSTPRIT
DEG_SCF_FBW7_1
0.2222
p.F128L
TCGA-XF-A9T3
BLCA
TCGA
PSTPRIT
DEG_SCF_FBW7_1
0.2778
p.F128L
DO51922
BLCA
ICGC
PSTPRIT
DEG_SCF_FBW7_1
0.2778
p.A119V
DO228122
EOPC
ICGC
PSTPRIT
DEG_SCF_FBW7_1
0.3056
p.P114L
DO234338
ESAD
ICGC
PSTPRIT
DEG_SCF_FBW7_1
0.1667
p.P114L
DO234303
ESAD
ICGC
PSTPRIT
DEG_SCF_FBW7_1
0.1667
p.P120S
DO233082
GACA
ICGC
PSTPRIT
DEG_SCF_FBW7_1
0.6752
p.R113S
DO228948
LICA
ICGC
PSTPRIT
DEG_SCF_FBW7_1
0.1389
p.R124M
DO228948
LICA
ICGC
PSTPRIT
DEG_SCF_FBW7_1
0.7521
p.P117L
DO23136
LINC
ICGC
PSTPRIT
DEG_SCF_FBW7_1
0.25
p.P120L
DO229177
LMS
ICGC
PSTPRIT
DEG_SCF_FBW7_1
0.6471
p.S110R
DO229257
THCA
ICGC
PSTPRIT
DEG_SCF_FBW7_1
0.5
p.P117S
SIDM00951
T-Lymphoblastic Leukemia
GDSC
PSTPRIT
DEG_SCF_FBW7_1
0.25
p.P117S
ACH-002222
Leukemia
CCLE
PSTPRIT
DEG_SCF_FBW7_1
0.25
p.A119T
ACH-000999
Colon/Colorectal Cancer
CCLE
PSTPRIT
DEG_SCF_FBW7_1
0.3056
p.T125M
MOG-G-UVW
central_nervous_system
COSMIC
PSTPRIT
DEG_SCF_FBW7_1
0.7423
Drug responses associated with TCEA2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PSTPRIT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q15560
Transcription elongation factor A protein 2
DEG_SCF_FBW7_1
120:126
PSTPRIT
FBXW7
0.996
More...