DegronMD

Uniprot ID: Q15560

Source protein: Transcription elongation factor A protein 2

Source gene: TCEA2

Class: DEG_SCF_FBW7_1

Location: 120:126

E3 ligase: FBXW7

DEGRON score: 0.996

ASA_SCORE: 95.1857

COIL: 0.9333

CONS_SCORE: 0.37

DSS_SCORE: 0.6304

HELIX: 0.027

FCONS_SCORE: 1.0521

RIG_SCORE: 0.6169

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S121L	TCGA-A5-A2K5	UCEC	TCGA	PSTPRIT	DEG_SCF_FBW7_1	0.7667
p.S121L	DO41379	UCEC	ICGC	PSTPRIT	DEG_SCF_FBW7_1	0.7667
p.R124M	DO228948	LICA	ICGC	PSTPRIT	DEG_SCF_FBW7_1	0.7521
p.T125M	MOG-G-UVW	central_nervous_system	COSMIC	PSTPRIT	DEG_SCF_FBW7_1	0.7423
p.P120S	DO233082	GACA	ICGC	PSTPRIT	DEG_SCF_FBW7_1	0.6752
p.P120L	DO229177	LMS	ICGC	PSTPRIT	DEG_SCF_FBW7_1	0.6471
p.S110R	DO229257	THCA	ICGC	PSTPRIT	DEG_SCF_FBW7_1	0.5
p.A119V	DO228122	EOPC	ICGC	PSTPRIT	DEG_SCF_FBW7_1	0.3056
p.A119T	ACH-000999	Colon/Colorectal Cancer	CCLE	PSTPRIT	DEG_SCF_FBW7_1	0.3056
p.F128L	TCGA-XF-A9T3	BLCA	TCGA	PSTPRIT	DEG_SCF_FBW7_1	0.2778
p.F128L	DO51922	BLCA	ICGC	PSTPRIT	DEG_SCF_FBW7_1	0.2778
p.P129L	TCGA-FS-A1YY	SKCM	TCGA	PSTPRIT	DEG_SCF_FBW7_1	0.25
p.P129L	DO37415	SKCM	ICGC	PSTPRIT	DEG_SCF_FBW7_1	0.25
p.P117L	DO23136	LINC	ICGC	PSTPRIT	DEG_SCF_FBW7_1	0.25
p.P117S	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PSTPRIT	DEG_SCF_FBW7_1	0.25
p.P117S	ACH-002222	Leukemia	CCLE	PSTPRIT	DEG_SCF_FBW7_1	0.25
p.P130T	TCGA-CV-7178	HNSC	TCGA	PSTPRIT	DEG_SCF_FBW7_1	0.2222
p.P130T	DO14774	HNSC	ICGC	PSTPRIT	DEG_SCF_FBW7_1	0.2222
p.P130Q	TCGA-D3-A3CB	SKCM	TCGA	PSTPRIT	DEG_SCF_FBW7_1	0.2222
p.P130Q	DO47386	SKCM	ICGC	PSTPRIT	DEG_SCF_FBW7_1	0.2222
p.P130S	TCGA-FS-A1YY	SKCM	TCGA	PSTPRIT	DEG_SCF_FBW7_1	0.2222
p.P130S	DO229177	LMS	ICGC	PSTPRIT	DEG_SCF_FBW7_1	0.2222
p.P130S	DO37415	SKCM	ICGC	PSTPRIT	DEG_SCF_FBW7_1	0.2222
p.P114L	DO234338	ESAD	ICGC	PSTPRIT	DEG_SCF_FBW7_1	0.1667
p.P114L	DO234303	ESAD	ICGC	PSTPRIT	DEG_SCF_FBW7_1	0.1667

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15560	Transcription elongation factor A protein 2	DEG_SCF_FBW7_1	120:126	PSTPRIT	FBXW7	0.996	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons