NFKBIB
UniProt ID: Q15653
Entrez ID: 4793
Protein name: NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkB-B) (IkB-beta) (IkappaBbeta) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9) (TRIP-9)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inh...
FUNCTION: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
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GO - Biological processes (BP):
cellular response to lipopolysaccharide [GO:0071222]; cytoplasmic sequestering of NF-kappaB [GO:0007253]; inflammatory response [GO:0006954]; regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122]; signal transduction [GO:0007165]; transcription, DNA-templated [GO:0006351]...
cellular response to lipopolysaccharide [GO:0071222]; cytoplasmic sequestering of NF-kappaB [GO:0007253]; inflammatory response [GO:0006954]; regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122]; signal transduction [GO:0007165]; transcription, DNA-templated [GO:0006351]
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GO - Molecular function (MF):
transcription coactivator activity [GO:0003713]...
transcription coactivator activity [GO:0003713]
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GO - Cellular component (CC):
cytosol [GO:0005829]; nucleus [GO:0005634]...
cytosol [GO:0005829]; nucleus [GO:0005634]
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NFKBIB
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*NOTE: the Kaplan plots were collected from OncoLnc